Heart Amyloid Deposits Studied in People With Alzheimer's Disease
Scans check for amyloid deposits in the heart of adults with Alzheimer's disease.
Plain-language title generated from the registry record
Registry title: Cardiac Amyloid Deposits and Heart Dysfunction in Alzheimer's Disease
Key facts
- Where
- Essen, GermanySee the site
Where in Germany
- University Hospital EssenEssen, GermanyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Essen
- Trial code
- NCT07154394
- Record updated
- 4 September 2025
- Original description
This study seeks to explore the possible common pathogenesis of both cardiac amyloidosis and Alzheimer's disease, which can both be associated with amyloid deposits. Using Positron Emission Tomography (PET) scans with amyloid tracers - a conventional tool for non-invasively imaging amyloid deposits in Alzheimer's disease - the research will extend this imaging methodology to the heart.Read full original descriptionShow less
Investigation of Cardiac Amyloid Deposits as a Cause of Cardiac Dysfunction in Alzheimer's Disease (Untersuchung Von Kardialen Amyloidablagerungen Als Ursache Einer Funktionseinschränkung Des Herzens Bei Alzheimer Demenz)
This study seeks to explore the possible common pathogenesis of both cardiac amyloidosis and Alzheimer's disease, which can both be associated with amyloid deposits. Using Positron Emission Tomography (PET) scans with amyloid tracers - a conventional tool for non-invasively imaging amyloid deposits in Alzheimer's disease - the research will extend this imaging methodology to the heart.
The study will conduct additional PET/MRI scans of the heart in patients undergoing amyloid tracer PET scans for Alzheimer's evaluations. Each participant will also undergo an echocardiogram and a clinical examination of dementia.
This could potentially enhance diagnostic practices in both cardiac amyloidosis and Alzheimer's disease.
Inclusion: Patients undergoing cerebral amyloid PET examination for clinical indication to clarify Alzheimer's disease; No contraindications to undergo an MRI examination; No contraindications to undergo an Amyloid PET scan.
Exclusion: Patients with vascular dementia and confirmed other causes of dementia (e.g. stroke, vitamin deficiency, thyroid insufficiency, toxic causes such as alcohol); Patients with pronounced cardiac preconditions; Pregnant and breastfeeding women.