Oxygen Delivery Methods for Sedated Stomach Scope Exams in Visceral Obesity
Compares high-flow nasal cannula with face mask oxygen in people with visceral obesity.
Plain-language title generated from the registry record
Registry title: High Flow Nasal Cannula and Mask Oxygenation in Patients With Visceral Obesity Undergoing Sedated Gastroscopy
Key facts
- Where
- Shanghai, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07159022, who can take part
Where in China
- Zhongshan HospitlaShanghai, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Shanghai Zhongshan Hospital
- Trial code
- NCT07159022
- Record updated
- 1 December 2025
- Original description
During sedated gastroscopy, the insertion of the fiberscope and gastric distension required to perform the examination may induce respiratory depression, airway obstruction, and decreased chest wall compliance. Patients with obesity, especially visceral fat, have poor lung and chest wall compliance, lower lung capacity and functional residual capacity, and an unbalanced ventilation-to-perfusion ratio. Thus, obese patients are at a high risk of hypoxemia.Read full original descriptionShow less
High Flow Nasal Cannula and Mask Oxygenation in Patients With Visceral Obesity Undergoing Sedated Gastroscopy: A Randomized Controlled Trial.
During sedated gastroscopy, the insertion of the fiberscope and gastric distension required to perform the examination may induce respiratory depression, airway obstruction, and decreased chest wall compliance. Patients with obesity, especially visceral fat, have poor lung and chest wall compliance, lower lung capacity and functional residual capacity, and an unbalanced ventilation-to-perfusion ratio. Thus, obese patients are at a high risk of hypoxemia.
Increasing evidence supports the use of High-flow nasal cannula (HFNC) oxygenation in obese patients during sedated gastrointestinal endoscopy. Obesity, especially visceral obesity, is an established risk factor associated with all-cause mortality. Body roundness index (BRI) is a newer anthropometric measure associated with identification of high-risk individuals. Owing to the limited evidence, we designed this unblinded randomized controlled trial to assess whether HFNC, compared to standard mask oxygenation, improves oxygenation at the end of the procedure (primary endpoint) in patients with visceral obesity.
Inclusion: ASA class ≤Ⅲ; Visceral obesity（body mass index≥28 and BRI ≥5.46）; Patients who will undergo sedated gastroscopy.
Exclusion: Recent (within 1 week) thoracic surgery; Emergent procedure or surgery; Life-threatening heart disease or acute myocardial infarction within 6 weeks; Upper respiratory tract infection; Nasal or nasopharyngeal diseases; Coagulation disorders or a tendency of nose bleeding; Allergy to drugs used during the procedure; Presence of pneumothorax or pulmonary bullae, pulmonary embolism, pulmonary oedema; Presence of tracheostomy; Pregnancy; Unwillingness to participate in the study.