Tests CPAP breathing treatment for sleep apnoea in people with difficult asthma
Tests CPAP treatment for sleep apnoea in adults with hard-to-control asthma.
Key facts
- Who runs it
- St. James's Hospital, Ireland
- Where
- Dublin, IrelandSee the site
- Trial code
- Registry title
- Obstructive Sleep Apnoea and Difficult Asthma (OSADA)
- Status
- Recruiting
- People taking part
- 80 people, planned
- Started
- 1 Sept 2025
- Planned end
- 22 May 2026
- Type of study
- Interventional, 3 groupsOne group gets no study treatment, for comparison.
- Treatments tested
- Continuous positive airway pressure (CPAP)
- Record updated
- 26 May 2026
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 18 to 90 with hard-to-control asthma. It studies whether finding and treating sleep apnoea with CPAP improves asthma control.
- Age
- 18 to 90 years
- Sex
- All sexes can join.
- Disease stage
- Asthma confirmed by a doctor and by tests, treated at step 4 or step 5 of the GINA treatment guidelines.
- Earlier treatment
- People with a previous sleep study cannot join.
- Biomarker or test result
- Tests supporting the asthma diagnosis, such as variable airflow blockage, airway over-reactivity, or signs of eosinophil inflammation (FeNO or blood eosinophils).
Main reasons for not taking part
- Previous sleep study
- Very strong daytime sleepiness (ESS above 17)
- Previous diagnosis of a sleep disorder
- Low oxygen at rest or need for long-term oxygen therapy
- Unable to give informed consent
The registry criteria, word for word
Show all 8 criteriaShow less
Who can take part
- Patients must have a clinical diagnosis of asthma with supportive objective diagnostics including but not limited to, variable airflow obstruction, bronchial-hyper responsiveness and demonstrable eosinophilic inflammation via fractional exhaled nitric oxide or peripheral eosinophilia
- Patients receiving step 4 or step 5 of 'The Global Initiative for Asthma' (GINA) treatment guidelines will be selected
- Between the ages of 18 to 90 years of age
Who cannot take part
- Patients with previous sleep study investigations
- Previous diagnosis of a sleep disorder
- Resting hypoxaemia or need for long-term oxygen therapy
- Excessive daytime sleepiness; ESS >17
- Inability to provide informed consent
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 90 years old?
Where in Ireland
- St. James's HospitalDublin, IrelandContact: Laura PiggottTaking people
About the trial
What the trial wants to find out
The OSADA (Obstructive Sleep Apnoea in Difficult Asthma) trial is an open-label, randomized control trial investigating the impact of diagnosing and treating obstructive sleep apnoea (OSA) on a asthma control in patients with difficult-to-control asthma.
Read full original descriptionShow less
Participants will undergo home-based sleep studies to assess for OSA and are then allocated to one of three arms: 1) Patients with OSA treated with CPAP (intervention group), 2) Patients with OSA not treated for OSA (control group) and 3) Patients without OSA (reference group).
The primary objective is to evaluate whether treating OSA improves asthma control, symptom burden, and quality of life compared to untreated OSA and to patients without OSA. Secondary outcomes include exacerbation rates, sleep quality, and healthcare utilization.
This trial aims to clarify the contribution of OSA to poor asthma control and the potential benefits of integrated sleep and respiratory care in this complex population.
The 3 groups in the trial
- Asthma - no sleep apnoeaNo study treatment, for comparison
This the group of asthma patients without sleep apnoea
- Asthma - sleep apnoea, no treatmentNo study treatment, for comparison
This the group of asthma patients with sleep apnoea (as defined as AHI ≥10 events per hour recorded) who have been randomized to the no treatment arm
- Asthma - sleep apnoea, treatmentTreatment being tested
This the group of asthma patients with sleep apnoea (as defined as AHI ≥10 events per hour recorded) who have been randomized to the treatment arm. They will receive CPAP therapy as treatment for sleep apnoea, while monitoring their asthma control measures and airflow variability.
Treatment: Continuous positive airway pressure (CPAP)
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Open-label Randomized Controlled Trial Investigating the Relationship Between Obstructive Sleep Apnoea and Difficult Asthma
- Plain-language title
- Tests CPAP breathing treatment for sleep apnoea in people with difficult asthmaGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT07160868, who can take part
- Record updated
- 26 May 2026