Tests home exercise for memory in adults with advanced kidney disease
Tests home walking and strength exercise in adults with advanced kidney disease and memory problems.
Plain-language title generated from the registry record
Registry title: Physical Exercise to Prevent Mild-cognitive Impairment in Patients With Kidney Disfunctions
Key facts
- Where
- Zurich, SwitzerlandSee the site
Where in Switzerland
- University of ZurichZurich, SwitzerlandNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Biogem s.c.ar.l.
- Trial code
- NCT07160959
- Record updated
- 8 September 2025
- Original description
This research project focuses on improving memory and thinking (cognitive function) in people with advanced chronic kidney disease (CKD), a condition that affects about 10% of adults and is often linked to cognitive problems. The study includes a clinical trial where patients will either receive standard care or follow a home-based exercise program involving walking and strength training, to see if regular physical activity can improve brain function. It also includes a large-scale analysis of data from the UK Biobank to explore blood and genetic markers, brain imaging, and lifestyle factors linked to cognitive health. The ultimate aim is to find effective, easy-to-implement strategies and early warning signs that could lead to better treatment and quality of life for people living with CKD.Read full original descriptionShow less
Physical Exercise to Prevent Mild-cognitive Impairment Progression in Advanced Chronic Kidney Disease (CKD) and Dialysis Patients
This research project focuses on improving memory and thinking (cognitive function) in people with advanced chronic kidney disease (CKD), a condition that affects about 10% of adults and is often linked to cognitive problems. The study includes a clinical trial where patients will either receive standard care or follow a home-based exercise program involving walking and strength training, to see if regular physical activity can improve brain function. It also includes a large-scale analysis of data from the UK Biobank to explore blood and genetic markers, brain imaging, and lifestyle factors linked to cognitive health. The ultimate aim is to find effective, easy-to-implement strategies and early warning signs that could lead to better treatment and quality of life for people living with CKD.
Inclusion: CKD at KDOQI stage 4-5; concomitant MCI (MOCA - MMSE (17 < MoCA < 26) or (16 < MMSE < 24).
Exclusion: Absolute contraindication to exercise training (e.g. unstable angina, major amputation, severe heart failure, etc.); Uncorrected anemia (Hb <9 g/dl); Known life expectancy < 6-month; Non-provision of informed consent.