Tests home exercise for memory in adults with advanced kidney disease
Tests home walking and strength exercise in adults with advanced kidney disease and memory problems.
Plain-language title generated from the registry record
Registry title: Physical Exercise to Prevent Mild-cognitive Impairment in Patients With Kidney Disfunctions
Key facts
- Where
- Ariano Irpino, ItalySee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with advanced chronic kidney disease (stage 4-5) who also have mild memory and thinking problems. It tests a home exercise program.
- Age
- 18 years or older
- Sex
- All sexes can join
- Disease stage
- Chronic kidney disease at KDOQI stage 4-5, together with mild cognitive impairment (MoCA score above 17 and below 26, or MMSE score above 16 and below 24)
Main reasons for not taking part
- Cannot do exercise training safely (for example unstable angina, major amputation, severe heart failure)
- Expected to live less than 6 months
- Uncorrected anemia (Hb below 9 g/dl)
- Does not give informed consent
Read by machine on 12 November 2026.
Where in Italy
- BiogemAriano Irpino, ItalyContact: Carminre ZoccaliNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Biogem s.c.ar.l.
- Trial code
- NCT07160959
- Record updated
- 8 September 2025
- Original description
This research project focuses on improving memory and thinking (cognitive function) in people with advanced chronic kidney disease (CKD), a condition that affects about 10% of adults and is often linked to cognitive problems. The study includes a clinical trial where patients will either receive standard care or follow a home-based exercise program involving walking and strength training, to see if regular physical activity can improve brain function. It also includes a large-scale analysis of data from the UK Biobank to explore blood and genetic markers, brain imaging, and lifestyle factors linked to cognitive health. The ultimate aim is to find effective, easy-to-implement strategies and early warning signs that could lead to better treatment and quality of life for people living with CKD.Read full original descriptionShow less
Physical Exercise to Prevent Mild-cognitive Impairment Progression in Advanced Chronic Kidney Disease (CKD) and Dialysis Patients
This research project focuses on improving memory and thinking (cognitive function) in people with advanced chronic kidney disease (CKD), a condition that affects about 10% of adults and is often linked to cognitive problems. The study includes a clinical trial where patients will either receive standard care or follow a home-based exercise program involving walking and strength training, to see if regular physical activity can improve brain function. It also includes a large-scale analysis of data from the UK Biobank to explore blood and genetic markers, brain imaging, and lifestyle factors linked to cognitive health. The ultimate aim is to find effective, easy-to-implement strategies and early warning signs that could lead to better treatment and quality of life for people living with CKD.
Inclusion: CKD at KDOQI stage 4-5; concomitant MCI (MOCA - MMSE (17 < MoCA < 26) or (16 < MMSE < 24).
Exclusion: Absolute contraindication to exercise training (e.g. unstable angina, major amputation, severe heart failure, etc.); Uncorrected anemia (Hb <9 g/dl); Known life expectancy < 6-month; Non-provision of informed consent.