Tests pulmonary rehabilitation to help lungs recover after tuberculosis
Tests lung rehabilitation exercise programs in adults being treated for tuberculosis.
Plain-language title generated from the registry record
Registry title: Parent Study Name: Pulmonary Rehabilitation to Reduce Post-Tuberculosis Morbidity (TB Pure)
Key facts
- Where
- Mangalore and Pune, IndiaSee the 2 sites
Where in India
- Yenepoya (Deemed to be UniversityMangalore, IndiaTaking people
- Symbiosis Medical College for Women & Symbiosis University Hospital and Research CenterPune, IndiaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Johns Hopkins University
- Trial code
- NCT07164742
- Record updated
- 27 March 2026
- Original description
Individual-level, unblinded randomized controlled trial of an 8-week (short arm) or 24-week (extended arm) pulmonary rehabilitation program, relative to standard of care, to prevent post-tuberculosis respiratory morbidity. Randomization will occur in a 1:1:1 ratio at the initiation of treatment.Read full original descriptionShow less
Pulmonary Rehabilitation to Reduce Post-Tuberculosis Morbidity (TB PURE) A Randomized Multi-Centre Trial
Individual-level, unblinded randomized controlled trial of an 8-week (short arm) or 24-week (extended arm) pulmonary rehabilitation program, relative to standard of care, to prevent post-tuberculosis respiratory morbidity. Randomization will occur in a 1:1:1 ratio at the initiation of treatment.
Inclusion: Age at least 18 years; Microbiologically confirmed (smear microscopy, GeneXpert or culture) pulmonary TB disease*; Not completed more than 2 weeks of TB treatment; Receiving TB care at the outpatient clinics at the TB PuRe study sites; Willingness to complete 48 weeks of study evaluations; Access to a smartphone.
Exclusion: Bronchodilators and/or corticosteroids inhaled or otherwise; Multi or extensively drug-resistant TB disease*; Extrapulmonary TB disease at any clinical sites without pulmonary involvement; Symptomatic cardiovascular disease, including coronary artery disease, arrhythmias and congestive cardiac failure; Any medical condition that prevents pulmonary rehabilitation eg: fracture of lower/upper limbs/pregnancy; Modified Medical Research Council score of 0 points (dyspnea only with strenuous exercise); TB meningitis or TB of the spine; Karnofsky Score < 40 points.