Studies which patient factors predict benefit from exercise rehabilitation in heart failure
Looks at whether blood microRNA levels relate to fitness gains in adults with heart failure.
Key facts
- Who runs it
- Centre Hospitalier de Corbie
- Where
- Corbie, FranceSee the site
- Trial code
- Registry title
- Predictive Factors of Response to Phase II Cardiac Rehabilitation in Heart Failure With Reduced Ejection Fraction
- Status
- Recruiting
- People taking part
- 62 people, planned
- Started
- 25 Nov 2025
- Expected to end
- 30 Nov 2027
- Type of study
- Observational
- Record updated
- 16 December 2025
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults aged 40 to 75 with heart failure and a weak pumping heart (ejection fraction below 40%) who have been prescribed phase II cardiac rehabilitation.
- Age
- 40 to 75 years
- Sex
- Men and women can join.
- Disease stage
- Heart failure with reduced ejection fraction below 40%, NYHA class II or higher, clinically stable for at least 6 weeks.
- Earlier treatment
- On optimized medical therapy for at least 6 weeks, with a prescription for phase II cardiac rehabilitation.
Main reasons for not taking part
- Cannot do regular adapted physical activity
- Uncontrolled high blood pressure
- Lung disease such as emphysema or COPD
- Other (secondary) heart or blood vessel disease
- Pregnant or breastfeeding women
The registry criteria, word for word
Show all 15 criteriaShow less
Who can take part
- Heart failure with reduced ejection fraction < 40%
- NYHA functional class ≥ II
- Clinically stable for at least 6 weeks
- On optimized medical therapy for at least 6 weeks
- Prescription for phase II cardiac rehabilitation
- BMI between 20-30 kg·m-²
- Physical activity level: sedentary or physically active but untrained
- Signed informed consent to participate in the study
- Affiliation to the French national health insurance system
Who cannot take part
- Uncontrolled arterial hypertension
- Secondary respiratory disease such as emphysema or chronic obstructive pulmonary disease (COPD)
- Secondary cardiovascular disease
- Contraindication to regular adapted physical activity
- Individuals under legal protection or deprived of liberty
- Pregnant or breastfeeding women
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 40 and 75 years old?
Where in France
- Hospital center of CorbieCorbie, FranceContact: Pierre-Marie Leprêtre, PhDTaking people
About the trial
What the trial wants to find out
Exercise intolerance, measured as peak oxygen consumption (VO₂peak) during exercise in patients with heart failure with reduced ejection fraction (HFrEF). Change in VO₂peak (ΔVO₂peak), which serves as a prognostic marker for HFrEF engaged in exercise based cardiac rehabilitation program (ExCR). Responders to ExCR generally show improved cardiac function but some patients with HFrEF do not respond to ExCR. VO₂peak depends on three major components of oxygen transport: Pulmonary (lungs), circulatory (heart and vessels) and skeletal muscle (oxygen utilization) functions. These physiological responses to ExCR may be influenced by epigenetic regulation, specifically the expression of circulating microRNAs (c-miRNAs).
Read full original descriptionShow less
Linking non-invasive measurements and epigenetic markers could 1) identify which component of the oxygen transport chain is most impaired and 2) allow personalized interventions to maximize VO₂peak improvements.
The primary objective of this stidy is to assess the association between changes in VO₂peak during exercise training and circulating microRNA expression (miR-146a, miR-191, miR-23a, miR-140, miR-1, miR-21, miR-133a, miR-17-5p, miR-3200-3p).
The secondary objective is to examine the relationship between pulmonary, cardiovascular, and neuromuscular adaptations to exercise and circulating microRNA expression.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Prédiction Des réponses du Patient Porteur d'Une Insuffisance Cardiaque à Fraction d'éjection altérée à Une Phase II de réadaptation Cardiaque
- Plain-language title
- Studies which patient factors predict benefit from exercise rehabilitation in heart failureGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Fit questions
- Built from NCT07164911, who can take part
- Record updated
- 16 December 2025