Tests a gluten-free diet in people with ankylosing spondylitis
Tests whether a gluten-free diet affects disease activity in adults with ankylosing spondylitis.
Plain-language title generated from the registry record
Registry title: The Impacts of Gluten-free Diet in Patients With Ankylosing Spondylitis
Key facts
- Where
- Istanbul, TürkiyeSee the 4 sites
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with axial spondyloarthritis (ankylosing spondylitis) on stable treatment. It tests a gluten-free diet against a control group.
- Age
- 18 to 64 years
- Sex
- All sexes can join.
- Disease stage
- Axial spondyloarthritis, diagnosed by ASAS criteria.
- Earlier treatment
- Stable treatment with an NSAID and/or DMARD for at least 3 months.
Main reasons for not taking part
- Any diet now or in the 3 months before joining
- History of celiac disease, ulcerative colitis, Crohn's disease or irritable bowel syndrome
- Type 1 or type 2 diabetes, or Hashimoto thyroiditis
- Pregnant or breastfeeding
- BMI under 18,50 kg/m2 or 29,99 kg/m2 and above
Read by machine on 12 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 64 years old?
Source: NCT07166874, who can take part
Where in Türkiye
- Bakırköy Dr. Sadi Konuk Training and Research HospitalIstanbul, TürkiyeContact: Gülay SezginTaking people
- Istanbul Medeniyet UniversityIstanbul, TürkiyeContact: Gülay SezginNo longer taking part
- İstanbul Sağlık Bilimleri UniversityIstanbul, TürkiyeContact: Gülay SezginNo longer taking part
- Marmara UniversityIstanbul, TürkiyeContact: Gülay SezginNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Saglik Bilimleri Universitesi
- Trial code
- NCT07166874
- Record updated
- 10 September 2025
- Original description
Subclinical intestinal inflammation and intestinal permeability have been reported in patients with ankylosing spondylitis. Gluten is one of the main triggers of zonulin releaseand gluten intake may contribute to the development of the disease by increasing intestinal permeability. This study aims to determine the impacts of a gluten-freediet on intestinal permeability, sub-clinical intestinal inflammation, disease activity, functional status and quality of life in patients with ankylosing spondylitis. The main questions it aims to answer are:Read full original descriptionShow less
The Impacts of Gluten Free Diet on Disease Activity, Quality of Life and Intestinal Permeability in Patients Diagnosed With Ankylosing Spondylitis.
Subclinical intestinal inflammation and intestinal permeability have been reported in patients with ankylosing spondylitis. Gluten is one of the main triggers of zonulin releaseand gluten intake may contribute to the development of the disease by increasing intestinal permeability. This study aims to determine the impacts of a gluten-freediet on intestinal permeability, sub-clinical intestinal inflammation, disease activity, functional status and quality of life in patients with ankylosing spondylitis. The main questions it aims to answer are:
Does a gluten-free diet have an effect on disease activity and functional status in patients with ankylosing spondylitis? Does a gluten-free diet have an effect on intestinal permeability and subclinical intestinal inflammation in patients with ankylosing spondylitis? The investigators will evaluate the effects of the gluten-free diet compared to a control group.
Inclusion: diagnosis of axial SpA defined by ASAS criteria; Adults (aged 18-64 years); stable treatment (NSAID and/or DMARD) for at least 3 months; provide written informed consent and submit to the requirements of the study.
Exclusion: Any diet at the time of inclusion or within 3 months prior to inclusion; have a history of celiac disease; have a history of Ulcerative Colitis, Crohn's Disease and Irritable Bowel Syndrom; patients with Type 1 and Type 2 Diabetes Mellitus; patients with Hashimoto Thyroiditis; are pregnant, breastfeeding,; patients who have used omega-3 and vitamins (A, C, E) regularly in the last 3 months; BMI <18,50 kg/m2; BMI ≥29,99 kg/m2.