Establishment and Clinical Application of Reference Intervals of Salivary Cortisol
Key facts
- Where
- Shanghai, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 80 years old?
Source: NCT07168122, who can take part
Where in China
- Shanghai Sixth People's HospitalShanghai, ChinaContact: Yufei Zhou, B.S.Taking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Shanghai 6th People's Hospital
- Trial code
- NCT07168122
- Record updated
- 11 September 2025
- Original description
The goal of this observational study is to establish the normal reference intervals of salivary cortisol and optimal cut-offs for Cushing's sydrome and adrenal insufficiency.Read full original descriptionShow less
Study for Reference Intervals and Optimal Cut-offs for Salivary Cortisol
The goal of this observational study is to establish the normal reference intervals of salivary cortisol and optimal cut-offs for Cushing's sydrome and adrenal insufficiency.
Inclusion: Age ≥ 18 and ≤ 60 years old; Body mass index (BMI) ≥ 18.5 and ≤ 24.9 kg*m\^-2; No previous history of chronic diseases such as hyperglycemia, hypertension, dyslipidemia, coronary heart disease and stroke; Normal glucose regulation, defined as: fasting blood-glucose < 5.6 mmol/L, 2-hour blood-glucose after glucose load < 7.8 mmol/L, and glycated hemoglobin (HbA1c) < 5.7%; Aged 18 to 80 years old; Patients with suspected Cushing's syndrome or adrenal insufficiency.
Exclusion: Corticosteroid therapy within the last 6 weeks; Pregnancy or lactation women, or people with cancer or mental illness; Factors affecting cortisol levels, including hypothalamus-pituitary-adrenal axis disease, autoimmune disease (systemic lupus erythematosus, rheumatoid arthritis, etc.), diagnosed mental disease, Alzheimer's disease, alcoholism (alcohol > 60 g/d for male, >40 g/d for women) and corticosteroid therapy in the past 3 months (females with contraceptives or estrogen); Factors affecting saliva collection, such as serious oral problems (oral ulcers, gingival bleeding); Acute infection (body temperature ≥ 37.3 ℃ or C-reactive protein > 50 mg/L); Cases:; Acute infection; Severe oral conditions; Alcoholism, depression, or other psychiatric disorders; Liver or kidney dysfunction, alanine aminotransferase (ALT) or aspartate aminotransferase (AST) or direct bilirubin higher than 1.5 times the upper limit of normal, or serum creatinine >115 μmol/L; Night shift workers, who are awake from 11:00 PM to 7:00 AM; Severe liver and kidney dysfunction.
Healthy Volunteers:.