Looking for Gene Targets in Ovarian Cancer Tumors
Studies gene activity in ovarian cancer tumor samples and cell lines to find targets.
Plain-language title generated from the registry record
Registry title: Identifying Genetic Targets in Gynecological Tumors
Key facts
- Where
- Reggio Emilia, ItalySee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adult women with a confirmed epithelial ovarian cancer, such as high-grade serous cancer. It studies genes and proteins in the tumour.
- Age
- 18 years or older
- Sex
- Women only
- Disease stage
- Epithelial ovarian cancer confirmed by tissue examination (high-grade serous, endometrioid, mucinous, clear cell or mesonephric-like types)
Main reasons for not taking part
- Refusing to sign the informed consent
- Low-grade ovarian tumour
- Non-epithelial ovarian tumour
- Clinical or pathology data missing or not enough
Read by machine on 12 November 2026.
Where in Italy
- Azienda USL IRCCS di Reggio EmiliaReggio Emilia, ItalyContact: Jasmine LonettiTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Azienda USL Reggio Emilia - IRCCS
- Trial code
- NCT07169396
- Record updated
- 24 July 2026
- Original description
This observational study aims to identfy genetic targets involved in the pathogenesis of gynecological tumors, with a focus on high-grade serous ovarian carcinoma. Using a triple approach - in silico, ex vivo and in vitro - the study will investigate the role of gonadotropins and their related signaling pathways in the epithelial ovarian cancers. Gene and protein expression levels will be evaluated through transcriptomic analysis, immunohistochemistry and functional assays on tumor cell lines. The goal is to uncover potential diagnostic or therapeutic targets in gynecological malignancies.Read full original descriptionShow less
Identification of Genetic Targets in Gynecological Tumors Via a Triple in Silico Ex-vivo / in Vivo Approach
This observational study aims to identfy genetic targets involved in the pathogenesis of gynecological tumors, with a focus on high-grade serous ovarian carcinoma. Using a triple approach - in silico, ex vivo and in vitro - the study will investigate the role of gonadotropins and their related signaling pathways in the epithelial ovarian cancers. Gene and protein expression levels will be evaluated through transcriptomic analysis, immunohistochemistry and functional assays on tumor cell lines. The goal is to uncover potential diagnostic or therapeutic targets in gynecological malignancies.
Inclusion: Adult women ≥18 years old; Histologically confirmed diagnosis of epithelial ovarian cancer (including high- grade serous, endometrioid, mucinous, clear cell, or mesonephric-like histotypes); Signed informed consent (for prospective cases) or ethically approved waiver (for retrospective samples).
Exclusion: Refusal to sign informed consent; Diagnosis of low-grade or non-epithelial ovarian tumors; Patients whose clinical or pathological data are unavailable or insufficient for study inclusion.