Taking people in ChinaNo phase

Observes how chronic hepatitis B treatments are used across China's hospitals

Follows adults with chronic hepatitis B on different antiviral treatments over time.

Plain-language title generated from the registry record
Registry title: Observation Study on Reducing the Risk of Liver Cancer Associated With Hepatitis B (Zhiyuan) Project.

Key facts

Where: Anyang, Guangzhou, Hebi, Jiaozuo, Jiayuguan, Jinan, Jiyuan, Kaifeng, Linyi, Luohe, Luoyang, Nanyang, Ningbo, Pingdingshan, Pingdu, Pujiang, Rizhao, Sanmenxia, Shangqiu, Xinxiang, Xinyang, Xuchang, Yantai, Zhengzhou, Zhongshan, Zhoukou, Zhumadian, and Zibo, ChinaSee the 162 sites

Where in China

Huaxian People's HospitalAnyang, ChinaTaking people
Linzhou City People's HospitalAnyang, ChinaTaking people
Neihuang County People's HospitalAnyang, ChinaTaking people
Tangyin County People's HospitalAnyang, ChinaTaking people
The Fifth People's Hospital of AnyangAnyang, ChinaTaking people
The First Affiliated Hospital of Xinxiang Medical University (Hua County Branch)Anyang, ChinaTaking people
Guangzhou First People's HospitalGuangzhou, ChinaTaking people
The First Affiliated Hospital of Jinan University (Guangzhou Overseas Chinese Hospital)Guangzhou, ChinaTaking people
Hebi Coal Mining Group General HospitalHebi, ChinaTaking people
Hebi Infectious Disease HospitalHebi, ChinaTaking people
Junxian County People's HospitalHebi, ChinaTaking people
Bo'ai County People's HospitalJiaozuo, ChinaTaking people
Mengzhou Hospital of Traditional Chinese MedicineJiaozuo, ChinaTaking people
Qinyang People's HospitalJiaozuo, ChinaTaking people
The Secend People's Hospital of JiaozuoJiaozuo, ChinaTaking people
The Third People's Hospital of JiaozuoJiaozuo, ChinaTaking people
Xiuwu People's HospitalJiaozuo, ChinaTaking people
Wenxian People's HospitalJiayuguan, ChinaTaking people
Jiyang County Hospital of Traditional Chinese MedicineJinan, ChinaTaking people
Shandong Public Health Clinical CenterJinan, ChinaTaking people
Jiyuan People's HospitalJiyuan, ChinaTaking people
Jiyuan Traditional Chinese Medicine HospitalJiyuan, ChinaTaking people
Huaihe Hospital of Henan UniversityKaifeng, ChinaTaking people
Infectious Diseases Hospital of KaifengKaifeng, ChinaTaking people
Kaifeng Central HospitalKaifeng, ChinaTaking people
Kaifeng Hospital of Traditional Chinese MedicineKaifeng, ChinaTaking people
Lankao First Hospital GroupKaifeng, ChinaTaking people
Qixian People's HospitalKaifeng, ChinaTaking people
The People's Hospital of WeishiKaifeng, ChinaTaking people
Tongxu County People's HospitalKaifeng, ChinaTaking people
Weishi County People's HospitalKaifeng, ChinaTaking people
Linyi Hospital of Traditional Chinese MedicineLinyi, ChinaTaking people
Linyi People's HospitalLinyi, ChinaTaking people
Linying County People's HospitalLuohe, ChinaTaking people
Luohe Central HospitalLuohe, ChinaTaking people
Luanchuan County People's HospitalLuoyang, ChinaTaking people
Luoning County People's HospitalLuoyang, ChinaTaking people
Luoyang Central HospitalLuoyang, ChinaTaking people
Luoyang First People's HospitalLuoyang, ChinaTaking people
Luoyang Third People's HospitalLuoyang, ChinaTaking people
Ruyang County People's HospitalLuoyang, ChinaTaking people
The First Affiliated Hospital of Henan University of Science and TechnologyLuoyang, ChinaTaking people
Xin'an County People's HospitalLuoyang, ChinaTaking people
Yichuan County Hospital of Traditional Chinese MedicineLuoyang, ChinaTaking people
Yiyang County People's HospitalLuoyang, ChinaTaking people
Dengzhou Central HospitalNanyang, ChinaTaking people
Dengzhou People's HospitalNanyang, ChinaTaking people
Fangcheng County People's HospitalNanyang, ChinaTaking people
Nanyang Central HospitalNanyang, ChinaTaking people
Nanyang First People's HospitalNanyang, ChinaTaking people
Nanyang Oilfield General HospitalNanyang, ChinaTaking people
Nanyang Second General HospitalNanyang, ChinaTaking people
Nanzhao County People's HospitalNanyang, ChinaTaking people
Neixiang County People's HospitalNanyang, ChinaTaking people
Sheqi County People's HospitalNanyang, ChinaTaking people
Tanghe County People's HospitalNanyang, ChinaTaking people
The First Affiliated Hospital of Nanyang Medical CollegeNanyang, ChinaTaking people
Xinye County People's HospitalNanyang, ChinaTaking people
Xixia County People's HospitalNanyang, ChinaTaking people
Zhenping People's HospitalNanyang, ChinaTaking people
Ningbo Medical Center Iihuili hospitalNingbo, ChinaTaking people
General Hospital Of Pingmei Shenma GroupPingdingshan, ChinaTaking people
Lushan County People's HospitalPingdingshan, ChinaTaking people
People's Hospital of BaofengPingdingshan, ChinaTaking people
Pingdingshan First People's HospitalPingdingshan, ChinaTaking people
Ruzhou First People's HospitalPingdingshan, ChinaTaking people
Ye County People's HospitalPingdingshan, ChinaTaking people
Pingdu Municipal People's HospitalPingdu, ChinaTaking people
Anyang District HospitalPujiang, ChinaTaking people
Chinese Medicine Hospital of puyangPujiang, ChinaTaking people
Fanxian People's HospitalPujiang, ChinaTaking people
Nanle County People's HospitalPujiang, ChinaTaking people
Puyang People's HospitalPujiang, ChinaTaking people
The Fifth People's Hospital of Puyang CityPujiang, ChinaTaking people
People's Hospital of RizhaoRizhao, ChinaTaking people
Huanghe Sanmenxia HospitalSanmenxia, ChinaTaking people
Sanmenxia Central HospitalSanmenxia, ChinaTaking people
The First People's Hospital of LingbaoSanmenxia, ChinaTaking people
The Sixth People's Hospital of LingbaoSanmenxia, ChinaTaking people
Yimei Group General HospitalSanmenxia, ChinaTaking people
Minquan County Hospital of Traditional Chinese MedicineShangqiu, ChinaTaking people
Minquan County People's HospitalShangqiu, ChinaTaking people
Second People's Hospital Xiayi CountryShangqiu, ChinaTaking people
Shangqiu Fourth People's HospitalShangqiu, ChinaTaking people
Shangqiu Hospital of Traditional Chinese MedicineShangqiu, ChinaTaking people
Shangqiu Municipal HospitalShangqiu, ChinaTaking people
Shangqiu Third People's HospitalShangqiu, ChinaTaking people
Sui County People's HospitalShangqiu, ChinaTaking people
Suixian County Hospital of Traditional Chinese MedicineShangqiu, ChinaTaking people
The First People's Hospital of ShangqiuShangqiu, ChinaTaking people
The People's Hospital of Yucheng CountyShangqiu, ChinaTaking people
Xiayi County People's HospitalShangqiu, ChinaTaking people
Yongcheng Central HospitalShangqiu, ChinaTaking people
Yucheng County People's HospitalShangqiu, ChinaTaking people
Zhecheng People's HospitalShangqiu, ChinaTaking people
Zhecheng Traditional Chinese Medicine Hospital Co., Ltd.Shangqiu, ChinaTaking people
Changyuan County People's HospitalXinxiang, ChinaTaking people
Huixian People's HospitalXinxiang, ChinaTaking people
The First Affiliated Hospital of Xinxiang Medical UniversityXinxiang, ChinaTaking people
The Third Affiliated Hospital of Xinxiang Medical UniversityXinxiang, ChinaTaking people
Xinxiang First People's HospitalXinxiang, ChinaTaking people
Xinxiang Infectious Disease HospitalXinxiang, ChinaTaking people
Yanjin County People's HospitalXinxiang, ChinaTaking people
Guangshan County People's HospitalXinyang, ChinaTaking people
Gushi County People's HospitalXinyang, ChinaTaking people
Huaibin County People's HospitalXinyang, ChinaTaking people
Huangchuan County People's HospitalXinyang, ChinaTaking people
Luoshan County People's HospitalXinyang, ChinaTaking people
Xinyang Central HospitalXinyang, ChinaTaking people
Xinyang Specialized Hospital for Infectious DiseasesXinyang, ChinaTaking people
Xixian People's HospitalXinyang, ChinaTaking people
Changge People's HospitalXuchang, ChinaTaking people
Xiangcheng County Traditional Chinese Medicine HospitalXuchang, ChinaTaking people
Xiangcheng People's HospitalXuchang, ChinaTaking people
Xuchang Central HospitalXuchang, ChinaTaking people
Xuchang People's HospitalXuchang, ChinaTaking people
Yanling County People's HospitalXuchang, ChinaTaking people
Yanling County Traditional Chinese Medicine HospitalXuchang, ChinaTaking people
Yuzhou Central HospitalXuchang, ChinaTaking people
Yuzhou City People's HospitalXuchang, ChinaTaking people
Chinese People's Liberation Army Joint Logistics Support Force 970 Hospital,Yantai, ChinaTaking people
Jiaozuo People's HospitalYantai, ChinaTaking people
Yantai Qishan HospitalYantai, ChinaTaking people
Gongyi City People's HospitalZhengzhou, ChinaTaking people
The First Affiliated Hospital of Henan University of Chinese MedicineZhengzhou, ChinaTaking people
The First Affiliated Hospital of Zhengzhou UniversityZhengzhou, ChinaTaking people
The First People's Hospit of ZhengzhouZhengzhou, ChinaTaking people
The Second Affiliated Hospital of Zhengzhou UniversityZhengzhou, ChinaTaking people
The Six People's Hospit of ZhengzhouZhengzhou, ChinaTaking people
The Third People's Hospit of ZhengzhouZhengzhou, ChinaTaking people
Third Affiliated Hospital of Henan University of Traditional Chinese MedicineZhengzhou, ChinaTaking people
Xingyang People's HospitalZhengzhou, ChinaTaking people
Zhengzhou Central HospitalZhengzhou, ChinaTaking people
Zhengzhou Traditional Chinese Medicine HospitalZhengzhou, ChinaTaking people
Zhongmu County Hospital of Traditional Chinese MedicineZhengzhou, ChinaTaking people
Zhongmu County People's HospitalZhengzhou, ChinaTaking people
Zhongshan Second People's HospitalZhongshan, ChinaTaking people
Dancheng County People's HospitalZhoukou, ChinaTaking people
Fugou County People's HospitalZhoukou, ChinaTaking people
Shenqiu People's HospitalZhoukou, ChinaTaking people
Taikang County People's HospitalZhoukou, ChinaTaking people
The Frist People's Hospital Of XiangchengZhoukou, ChinaTaking people
The People's Hospital Of LuyiZhoukou, ChinaTaking people
Xihua County Hospital of Traditional Chinese MedicineZhoukou, ChinaTaking people
Xihua County People's HospitalZhoukou, ChinaTaking people
Zhoukou Central HospitalZhoukou, ChinaTaking people
Zhoukou Hospital Of TCMZhoukou, ChinaTaking people
Zhoukou Specialized Disease HospitalZhoukou, ChinaTaking people
People's Hospital of QueshanZhumadian, ChinaTaking people
Pingyu County People's HospitalZhumadian, ChinaTaking people
Runan County Hospital of Traditional Chinese MedicineZhumadian, ChinaTaking people
Shangcai County People's HospitalZhumadian, ChinaTaking people
The 990th Hospital of the Joint Logistics Support Force of the PLAZhumadian, ChinaTaking people
The People's Hospital Of Biyang CountryZhumadian, ChinaTaking people
Xincai County People's HospitalZhumadian, ChinaTaking people
Xincai Medical UniversityZhumadian, ChinaTaking people
Xiping County People's HospitalZhumadian, ChinaTaking people
Zhengyang County People's HospitalZhumadian, ChinaTaking people
Zhumadian Central HospitalZhumadian, ChinaTaking people
Zhumadian Traditional Chinese Medicine HospitalZhumadian, ChinaTaking people
Zibo Central hospitalZibo, ChinaTaking people
Zibo Infectious Diseases Hospital (Zibo Fourth People's Hospital)Zibo, ChinaTaking people

Questions to ask the study team

How often do I need to come in, and for how long each time?
Are travel costs paid?
Can I keep my own doctor?
What happens if I want to stop?

Print a page for my doctor

Trial details

Who runs it: The First Affiliated Hospital of Zhengzhou University
Trial code: NCT07169656
Record updated: 12 September 2025
Original description: This study is a multicenter, prospective, observational real-world study designed to investigate and analyze the current treatment patterns of chronic hepatitis B (CHB) across 200 hospitals in China. By comparing patient outcomes under different therapeutic regimens, it aims to provide high-quality evidence-based medical data to optimize CHB treatment strategies and follow-up protocols, ultimately contributing to the advancement of a functional cure for chronic hepatitis B.Read full original descriptionShow less
Observation Study on Reducing the Risk of Liver Cancer Associated With Hepatitis B (Zhiyuan) Project.
This study is a multicenter, prospective, observational real-world study designed to investigate and analyze the current treatment patterns of chronic hepatitis B (CHB) across 200 hospitals in China. By comparing patient outcomes under different therapeutic regimens, it aims to provide high-quality evidence-based medical data to optimize CHB treatment strategies and follow-up protocols, ultimately contributing to the advancement of a functional cure for chronic hepatitis B.
Inclusion: 1.Chronic HBV infection (HBsAg-positive for ≥6 months); 2.Age ≥18 years; 3.Patients who, based on real-world clinical practice needs, are planned or currently receiving treatment with:Entecavir (ETV),Tenofovir disoproxil fumarate (TDF),Tenofovir alafenamide fumarate (TAF),Tenofovir amibufenamide (TMF) OR Pegylated interferon α-2b-naïve patients OR Patients re-initiating pegylated interferon α-2b therapy; 4.Written informed consent obtained from the patient.
Exclusion: 1.Severe hepatic dysfunction or decompensated cirrhosis; 2.Concurrent participation in other clinical trials; 3.Hepatocellular carcinoma (HCC).
ClinicalTrials.gov NCT07169656