Single vs Multi-Dose Insulin for Glycemic Control (SUGAR)
Key facts
- Who runs it
- Rutgers, The State University of New Jersey
- Where
- New Brunswick and New York, United StatesSee the 2 sites
- Trial code
- Status
- Recruiting
- People taking part
- 176 people, planned
- Started
- 26 Nov 2025
- Expected to end
- 15 May 2027
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Insulin glargine alone
- Insulin glargine + insulin lispro
- Record updated
- 16 April 2026
Who can take part
- Age
- 18 years to 50 years
- Sex
- Women only
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 9 criteriaShow less
Who can take part
- Diagnosed with type 2 diabetes mellitus or A2 gestational diabetes mellitus requiring insulin use during pregnancy
- Aged between 18-50
- Speak English or Spanish
Who cannot take part
- Contraindication to Lispro or Lantus insulin, or patient chooses to not utilize insulin therapy
- Gestational Age > or = 35w0d
- Pre-existing use of insulin
- Planning to follow-up with a doctor not associated with RWJ Barnabas or NYU Langone Health and/or deliver at a hospital other than RWJUH or NYU
- Unwilling or unable to upload or email weekly blood sugar logs
- Fetal anomaly present
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 50 years old?
Where in United States
- Robert Wood Johnson Univeristy HospitalNew Brunswick, United StatesContact: Emily Rosenfeld, DOTaking people
- Maternal-Fetal Medicine at NYU Langone Obstetrics & Gynecology AssociatesNew York, United StatesContact: Lucia MuzzarelliNot yet recruiting
About the trial
What the trial wants to find out
The goal of this clinical trial is to see if diabetes in pregnancy can be treated with once daily dosing of insulin instead of once daily dosing plus insulin with meals. The main question this study aims to answer is:
Read full original descriptionShow less
1. Can a once daily dose of long-acting insulin control blood sugars as well as long-acting insulin plus meal-time insulin? 2. Do babies born to mothers who take one dose of long-acting insulin have more complications after birth than babies born to mothers who take long-acting and meal-time insulin? Researchers will compare one dose of long-acting insulin per day to this plus three doses of short-acting insulin with each meal to see if blood sugars are controlled.
Participants will send their blood sugar logs to the study staff weekly, instead of to their OB/GYN, for adjustments to their insulin dosing.
The 2 groups in the trial
- Insulin glargine aloneTreatment being tested
Once daily dosing of insulin glargine
- Insulin glargine + Insulin lisproExisting treatment, for comparison
Once daily dosing of insulin glargine plus three times per day dosing of insulin lispro with each meal
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Single vs Multi-Dose Insulin for Glycemic Control (SUGAR): A Randomized Noninferiority Trial
- Fit questions
- Built from NCT07171684, who can take part
- Record updated
- 16 April 2026