Classifying microembolic signals seen on transcranial Doppler ultrasound in stroke research
Experts review blood-flow ultrasound recordings to classify tiny clots in adults at risk of stroke.
Plain-language title generated from the registry record
Registry title: A Multicenter Study to Optimize Microembolic Signal Classification Based on Double--Blind Multiparametric Assessment by Human Experts Using an Universal Graphical Interface [MESOMEGA]
Key facts
- Where
- Porto, PortugalSee the site
Where in Portugal
- Faculty of Medicine University PortoPorto, PortugalNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Universidade do Porto
- Trial code
- NCT07172165
- Record updated
- 10 December 2025
- Original description
Microembolic signals (MES) is a powerful predictor of future embolic events. This study aims to develop and validate a accurate model of classification of MES obtained by transcranial Doppler. monitoring of However, MES detection is technically demanding and requires expert interpretation. By providing a reproducible framework for MES interpretation, this work aims to facilitate MES integration into future clinical trials and decision-making.Read full original descriptionShow less
A Multicenter Study to Optimize Microembolic Signal Classification Based on Double--Blind Multiparametric Assessment by Human Experts Using an Universal Graphical Interface [MESOMEGA]
Microembolic signals (MES) is a powerful predictor of future embolic events. This study aims to develop and validate a accurate model of classification of MES obtained by transcranial Doppler. monitoring of However, MES detection is technically demanding and requires expert interpretation. By providing a reproducible framework for MES interpretation, this work aims to facilitate MES integration into future clinical trials and decision-making.
Inclusion: MES of presumed solid form or non-MES high intensity transient signals; Obtained from on a human subject with age equal to or more than 18years old; Obtained from proximal middle cerebral artery (M1 segment); Clip with 20 seconds duration with clearly event of interest marked using TCDPlayer; With an overall background spectrum of reasonable quality to be analyzed.
Exclusion: Use of ultrasound contrast agent or agitated saline in the previous 24 hours; Obtained from patient during any cardiac surgery or endovascular procedure1; MES in gaseous form; Obtained from patients with mechanical valve; Obtained from patient with recent severe trauma; Clips with multiples inseparable MES (e.g. curtain).