Testing a spinal fluid marker to help diagnose multiple sclerosis
Compares a spinal fluid test with an older test in people with multiple sclerosis.
Plain-language title generated from the registry record
Registry title: Kappa Free Light Chains (KFLC) in Multiple Sclerosis (MS) and Clinically Isolated Syndrome (CIS)
Key facts
- Where
- Hanover, GermanySee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 70 years old?
Source: NCT07183020, who can take part
Where in Germany
- Medizinische Hochschule Hannover / Hannover Medical SchoolHanover, GermanyNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Skripuletz, Thomas Prof. Dr.
- Trial code
- NCT07183020
- Record updated
- 19 September 2025
- Original description
The goal of this observational study is to learn about the role of kappa free light chains (KFLC) in cerebrospinal fluid (CSF) in the diagnosis of multiple sclerosis (MS) and clinically isolated syndrome (CIS). The main question it aims to answer is:Read full original descriptionShow less
Prospective, Multicentric, Real-world Investigation of Kappa Free Light Chains (KFLC) in Multiple Sclerosis (MS) and Clinically Isolated Syndrome (CIS)
The goal of this observational study is to learn about the role of kappa free light chains (KFLC) in cerebrospinal fluid (CSF) in the diagnosis of multiple sclerosis (MS) and clinically isolated syndrome (CIS). The main question it aims to answer is:
Are KFLC superior, inferior or equally useful in the diagnostic work-up of CSF of patients with MS and CIS?
In CSF and serum sample pairs of patients diagnosed with MS or CIS, KFLC are measured using a nephelometric assay and are compared with the gold standard, of CSF diagnostics, oligoclonal bands.
Inclusion: patients diagnosed with multiple sclerosis (MS) or clinically isolated syndrome (CIS) according to 2017-revised McDonald criteria for MS; age between 18 and 70 years.
Exclusion: no available cerebrospinal fluid (CSF) and serum sample pairs; no diagnosis of MS or CIS according to 2017-revised McDonald criteria for MS.