Tests MRI-guided magnetic brain stimulation for depression in teenagers
Tests MRI-guided magnetic brain stimulation in teenagers aged 12 to 18 with depression.
Plain-language title generated from the registry record
Registry title: Feasibility, Safety, and Preliminary Clinical Efficacy of Magnetic Resonance Imaging-guided Repetitive Transcranial Magnetic Stimulation (rTMS) in Adolescents With Depression: A Randomized, Double-Blind, Controlled Pilot Study
Key facts
- Where
- Chongqing, ChinaSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adolescents aged 12 to 18 who are currently in a depressive episode of major depressive disorder and take stable psychiatric medication.
- Age
- 12 to 18 years
- Sex
- All sexes can join.
- Disease stage
- Major depressive disorder (DSM-5), currently in a depressive episode, confirmed with the K-SADS-PL, with a score of 40 or higher on the CDRS-R.
- Earlier treatment
- At least 4 weeks of stable psychiatric medication before joining, and the same medication throughout the study. No earlier ECT, TMS, tDCS, tACS or other neuromodulation treatment.
Main reasons for not taking part
- Other psychiatric conditions, except anxiety disorders
- Depression with psychotic symptoms
- YMRS score above 13
- Neurological disorders or severe physical illness
- Pregnant or breastfeeding women
Read by machine on 9 November 2026.
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 12 and 18 years old?
Source: NCT07185438, who can take part
Where in China
- The First Affiliated Hospital of Chongqing Medical UniversityChongqing, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- First Affiliated Hospital of Chongqing Medical University
- Trial code
- NCT07185438
- Record updated
- 26 May 2026
- Original description
This study aims to assess the feasibility, safety, acceptability, and preliminary efficacy trends of a Magnetic Resonance Imaging-guided Repetitive Transcranial Magnetic Stimulation (rTMS) intervention for adolescent depression through a pilot clinical trial. The findings will inform the design and optimization of subsequent formal randomized controlled trials, providing essential evidence for their execution.Read full original descriptionShow less
Feasibility, Safety, and Preliminary Clinical Efficacy of Magnetic Resonance Imaging-guided Repetitive Transcranial Magnetic Stimulation (rTMS) in Adolescents With Depression: A Randomized, Double-Blind, Controlled Pilot Study
This study aims to assess the feasibility, safety, acceptability, and preliminary efficacy trends of a Magnetic Resonance Imaging-guided Repetitive Transcranial Magnetic Stimulation (rTMS) intervention for adolescent depression through a pilot clinical trial. The findings will inform the design and optimization of subsequent formal randomized controlled trials, providing essential evidence for their execution.
Inclusion: Age 12 - 18; Diagnosis of major depressive disorder (MDD) according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), confirmed through the Kiddie Schedule for Affective Disorders and Schizophrenia - Present and Lifetime version (K-SADS-PL), currently in a depressive episode; Score≥40 on the CDRS-R; Stable pharmacological treatment: At least 4 weeks of stable psychiatric medication use prior to enrollment, with continuation of the same psychiatric medication regimen throughout the study.
Exclusion: Patients currently using anticonvulsants or high-dose benzodiazepines; Psychiatric comorbidities other than anxiety disorders; A history of neurological disorders (e.g., epilepsy, brain injury) or severe somatic diseases (e.g., thyroid disorders, lupus, diabetes, pulmonary, hepatic, or renal impairment, major trauma); A history of electroconvulsive therapy (ECT), transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), transcranial alternating current stimulation (tACS), or other neuromodulation treatments; A history of alcohol or substance abuse or dependence; Potential complicating factors related to transcranial magnetic stimulation, such as scalp conditions or perforations that may affect magnetic field delivery; Depression with psychotic symptoms; Young Mania Rating Scale (YMRS) score >13; Women who are pregnant or breastfeeding; Current high suicide risk; Contraindications to MRI.