Tests deep brain stimulation for muscle stiffness after stroke
Tests brain stimulation at different settings in adults with stroke-related stiffness.
Plain-language title generated from the registry record
Registry title: Deep Anterior Cerebellar Stimulation in Treatment of Poststroke Spasticity and Motor Function Impairment.
Key facts
- Where
- Bydgoszcz, PolandSee the site
AI summary: who the study is looking for
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults who had one stroke 9-36 months ago and still have stiff, spastic muscles in at least one limb. They have had rehabilitation without improvement.
- Age
- 18 years and older
- Sex
- All sexes can join.
- Disease stage
- One stroke (ischemic or hemorrhagic) 9-36 months ago, with spastic paresis of at least one limb.
- Earlier treatment
- At least 3 months of rehabilitation after the stroke in the past, with no improvement of spasticity or motor function for at least 3 months.
Main reasons for not taking part
- Seizures after the stroke
- Depression
- Severe sensory deficits
- Moderate to severe hemispatial neglect
- Contraindication for MRI or for the DBS procedure
Read by machine on 12 November 2026.
Where in Poland
- Department of Neurosurgery and Neurology University Hospital nr 2 Collegium Medicum Nicolaus Copernicus UniversityBydgoszcz, PolandContact: Paweł Sokal, Ph.D.Taking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Jan Biziel University Hospital No 2 in Bydgoszcz
- Trial code
- NCT07190092
- Record updated
- 24 September 2025
- Original description
The aim of this clinical trial is to determine whether deep brain stimulation (DBS) interventions improve rehabilitation and functional recovery in patients with post-stroke spasticity who meet the other inclusion criteria listed below.Read full original descriptionShow less
Deep Anterior Cerebellar Stimulation in Treatment of Poststroke Spasticity and Motor Function Impairment.
The aim of this clinical trial is to determine whether deep brain stimulation (DBS) interventions improve rehabilitation and functional recovery in patients with post-stroke spasticity who meet the other inclusion criteria listed below.
Primary question(s) to be answered:
Is DBS stimulation effective in treating post-stroke spasticity? What stimulation frequency is most effective in treating post-stroke spasticity?
Study participants will:
* Undergo surgery to implant a DBS electrode targeting the DRTt (dentate-rubro-thalamic tract ) in close proximity of the dentate nucleus of the cerebellum ipsilateral to the spastic side of the body. * Each patient will then receive an initial stimulation frequency of 130 Hz (arm 1) and will be assigned to a 4- to 6-week rehabilitation program. After this period, the participant will return for a follow-up visit for a clinical evaluation. * The frequency will then be changed to 70Hz (arm 2). Patients who have undergone this change will also undergo a rehabilitation period of 4 to 6 weeks. After this period, they will return to the Clinic for a follow-up evaluation. * The frequency will then be changed to 30Hz (arm 3). Patients who have undergone this change will also undergo a rehabilitation period of 4 to 6 weeks.
Researchers will compare the results obtained from patients in each arm to determine the clinical effects of stimulation and whether they are dependent on the stimulation frequency.
Inclusion: One time stroke that occurred 9-36 months ago; Ischemic or hemorrhagic stroke; Spastic paresis of at least one limb; At least 3 months of poststroke rehabilitation in the past; No improvement of spasticity/motor function for at least 3 months.
Exclusion: Seizures after the stroke; Others contraindications for the DBS procedure, e.g. coagulopathy, decompensated chronic disease, etc; Depression; Severe sensory deficits; Anosognosia; Moderate to severe hemispatial neglect; Contraindication for MRI; No poststroke rehabilitation.