Removing Leftover Rectal Lesions by Endoscopy After Chemoradiation
Compares endoscopic removal of leftover rectal lesions with watchful follow-up in adults.
Plain-language title generated from the registry record
Registry title: ESD in Locally Advanced Rectal Cancer Following CRT
Key facts
- Where
- Asyut, EgyptSee the site
Where in Egypt
- Assiut UniversityAsyut, EgyptNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Assiut University
- Trial code
- NCT07192627
- Record updated
- 25 September 2025
- Original description
residual mucosal lesions in patients with locally advanced rectal cancer after CRT are still confusing for decision to continue follow up or excise.Read full original descriptionShow less
Selective Endoscopic Resection vs. Surveillance Following CRT for Rectal Cancer: 1-Year Oncologic and Functional Outcomes
residual mucosal lesions in patients with locally advanced rectal cancer after CRT are still confusing for decision to continue follow up or excise.
Investigators decided to compare two groups with cCR or nCR with MDT management decision to whether do ESD for this residual lesion or continue follow up and its effect on disease free survival.
Inclusion: Adult patients with rectal adenocarcinoma who underwent full course locoregional chemoradiotherapy with organ-preservation intent; Post-CRT assessment showing either:; Small residual mucosal/submucosal lesion amenable to en-bloc ESD (CRT→ESD), OR B. Clinical/radiologic near-complete/complete response and decision to observe (CRT→Follow-up).
Exclusion: Lesions unsuitable for endoscopic resection (circumferential, deeply invasive on EUS/MRI); - Evidence of distant metastasis at post-CRT restaging; Patients who had immediate TME after CRT for other reasons; Unfit for endoscopy or follow-up.