Intra-Articular Polyacrylamide Hydrogel Injections Improve Pain and Function in Knee Osteoarthritis
Key facts
- Who runs it
- Feza Korkusuz MD
- Where
- Türkiye1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 387 people enrolled
- Started
- 11 Feb 2023
- Ended
- 24 Jun 2025
- Type of study
- Observational
- Treatments tested
- Polyacrylamide hydrogel 2.5% intra-articular injection
- Record updated
- 25 September 2025
Who can take part
- Age
- 40 years and older
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
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Who can take part
- Age ≥ 40 years
- Radiographic diagnosis of knee osteoarthritis (Kellgren-Lawrence grade 2-4)
- Received intra-articular 2.5% polyacrylamide hydrogel injection
Who cannot take part
- Prior knee surgery before PAAG injection
- Malignancy, local infection, or septic arthritis
- Inflammatory joint disease (e.g., rheumatoid arthritis)
- Pregnancy
- Avascular necrosis
- Advanced varus or valgus knee deformity
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
This study is designed to evaluate the effects of intra-articular injections of polyacrylamide hydrogel (Arthrosamid®) in patients with knee osteoarthritis. A total of 387 patients (593 knees) were treated across three medical centers in Türkiye.
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The purpose of the study is to determine whether this injection can reduce knee pain and improve physical function in everyday life. Pain is being measured using a Visual Analogue Scale (VAS), and function is being assessed with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).
The group in the trial
- Knee Osteoarthritis Patients
Patients diagnosed with knee osteoarthritis (Kellgren-Lawrence grade 2-4) who received a single intra-articular injection of 2.5% polyacrylamide hydrogel (Arthrosamid®, Contura, Denmark). Followed retrospectively for 12 months to assess pain (VAS) and function (WOMAC).
Treatment: Polyacrylamide hydrogel 2.5% intra-articular injection
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Intra-Articular Polyacrylamide Hydrogel Injections Improve Pain and Function in Knee Osteoarthritis: A Multicenter Retrospective Study.
- Record updated
- 25 September 2025