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Studies cells surrounding eggs in women with PCOS during IVM

Examines gene activity in cumulus cells from women with PCOS undergoing egg maturation.

Plain-language title generated from the registry record
Registry title: Transcriptomic Profiling of Cumulus Cells From CAPA-IVM

Key facts

Where
Ho Chi Minh City, VietnamSee the site

AI summary: who the study is looking for

From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.

The trial is looking for women aged 18 to 38 with polycystic ovary syndrome (PCOS) who are indicated for CAPA-IVM treatment (a type of in vitro maturation of eggs).

Age
18 to 38 years
Sex
Women only
Disease stage
PCOS diagnosed by the Rotterdam 2003 criteria (at least 2 of 3 features: irregular or no ovulation, signs of high male hormones, polycystic ovaries on ultrasound). Antral follicle count of 24 or more in both ovaries.
Earlier treatment
Must be indicated for CAPA-IVM treatment. A previous IVF cycle where all eggs were immature is an exclusion.
Biomarker or test result
Serum AMH 4 ng/mL (28.57 pmol/L) or higher.

Main reasons for not taking part

  • Sperm retrieved from surgical procedures
  • Previous IVF cycle with only immature eggs
  • BMI above 32 kg/m2

Read by machine on 12 November 2026.

Could this be for you?

Answer for yourself. This is not a decision: only the study team can say whether you can take part.

  • Are you between 18 and 38 years old?

Source: NCT07197255, who can take part

Where in Vietnam

  • My Duc HospitalHo Chi Minh City, VietnamContact: Tuong M Ho, MDTaking people

Questions to ask the study team

  1. How often do I need to come in, and for how long each time?
  2. Are travel costs paid?
  3. Can I keep my own doctor?
  4. What happens if I want to stop?

Contact the study team: see the registry record → Contacts and Locations

Print a page for my doctor

Trial details

Who runs it
Mỹ Đức Hospital
Trial code
NCT07197255
Record updated
21 November 2025
Original description
Capacitation in vitro maturation (CAPA-IVM) has improved oocyte maturation and resulted in live births. Because cumulus cells (CCs) communicate bidirectionally with the oocyte, their transcriptomic profile may serve as a non-invasive biomarker of oocyte and embryo competence. This prospective pilot study will analyze CCs gene expression after CAPA-IVM using RNA sequencing and pathway analysis, and correlate findings with embryological outcomes including fertilization, day-3 cleavage, and blastocyst formation. Results are expected to provide insights into the molecular basis of oocyte competence and support development of non-invasive embryo selection strategies.Read full original descriptionShow less

Transcriptomic Profiling of Cumulus Cells From CAPA-IVM Cycles in Women With PCOS: A Prospective Pilot Study

Capacitation in vitro maturation (CAPA-IVM) has improved oocyte maturation and resulted in live births. Because cumulus cells (CCs) communicate bidirectionally with the oocyte, their transcriptomic profile may serve as a non-invasive biomarker of oocyte and embryo competence. This prospective pilot study will analyze CCs gene expression after CAPA-IVM using RNA sequencing and pathway analysis, and correlate findings with embryological outcomes including fertilization, day-3 cleavage, and blastocyst formation. Results are expected to provide insights into the molecular basis of oocyte competence and support development of non-invasive embryo selection strategies.

Inclusion: Women 18-38 years; BMI =< 32kg/m2; Diagnosed with polycystic ovary syndrome (PCOS) according to the Rotterdam 2003 criteria, meet at least 2 of the following 3 features: (1) Oligo-ovulation or anovulation. (2) Clinical and/or biochemical signs of hyperandrogenism (3) Polycystic ovarian morphology on ultrasound; Indicated for CAPA-IVM treatment; Serum AMH ≥ 4 ng/mL (28.57 pmol/L); Antral follicle count (AFC) ≥ 24 follicles in both ovaries at the time of CAPA-IVM indication; Signed informed consent to participate in the study.

Exclusion: Retrieved sperm from surgical procedures; Previous IVF cycle with total immature oocytes.

ClinicalTrials.gov NCT07197255