Postpartum bundle program for women after preeclampsia in a first pregnancy
Tests a postpartum bundle program to improve heart and metabolic health after preeclampsia.
Plain-language title generated from the registry record
Registry title: The PreEclampsia Postpartum Prevention Trial
Key facts
- Where
- Stockholm, SwedenSee the 2 sites
Where in Sweden
- Karolinska InstitutetStockholm, SwedenTaking people
- Karolinska University HospitalStockholm, SwedenTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Karolinska Institutet
- Trial code
- NCT07199283
- Record updated
- 12 August 2026
- Original description
The goal of this clinical trial is to learn if a postpartum bundle intervention can improve cardiometabolic health and lifestyle-related factors in women who have had preeclampsia during their first pregnancy. The main questions it aims to answer are:Read full original descriptionShow less
The PEPP Trial: A Postpartum Bundle Intervention to Improve Cardiometabolic Health in Women After a First Pregnancy Affected by Preeclampsia - a Multi-centre Randomised Controlled Trial
The goal of this clinical trial is to learn if a postpartum bundle intervention can improve cardiometabolic health and lifestyle-related factors in women who have had preeclampsia during their first pregnancy. The main questions it aims to answer are:
* Does the 9-month intervention reduce systolic and diastolic blood pressure? * Does the intervention promote postpartum weight loss? * Does the intervention affect weight and blood pressure depending on early pregnancy BMI? Researchers will compare the bundle intervention to standard care to see if the intervention improves cardiometabolic health and lifestyle outcomes.
All participants will attend clinical visits for outcome assessments.
Participants in the intervention group will:
* Receive online targeted screening and group meetings with study personnel * Use the trial-specific PEPP app to access self-monitoring tools for blood pressure and weight, lifestyle modification, and health education * Follow the intervention in two phases: starting after inclusion (≈8 weeks postpartum) with a Light phase (baseline-3 months) and progressing to an Intensive phase (3-9 months)
Inclusion: First-time mothers postpartum; Preeclampsia during first pregnancy; Age ≥ 18 years; Singleton live birth (infant still alive); Ability to understand and speak Swedish, English; Having a smartphone (Android or iOS); Ability to provide informed consent.
Exclusion: Previous or current eating disorders; Pre-pregnancy hypertension; Diabetes mellitus type I or II; Cardiovascular disease; Kidney disease; Antiphospholipid syndrome; Systemic lupus erythematosus; Ongoing new pregnancy.