Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI)

Trial details

Who runs it

Zealand University Hospital

Trial code

NCT07200739

Record updated

2 September 2026

Original description

The goal of this observational study is to learn if an artificial intelligence (AI)-based speech analysis tool can identify which patients with memory problems need specialist evaluation at a memory clinic. The main questions it aims to answer are:Read full original descriptionShow less

Development of Deep Learning Models for Detection of Neurodegenerative Diseases Using Speech - a Danish Language-based Artificial Intelligence Study (DetectAI)

The goal of this observational study is to learn if an artificial intelligence (AI)-based speech analysis tool can identify which patients with memory problems need specialist evaluation at a memory clinic. The main questions it aims to answer are:

Can the AI model accurately distinguish between patients who need referral to a memory clinic (those with dementia or Mild Cognitive Impairment) and patients who don't (those with normal cognition or memory problems from other causes like depression)? Which speech patterns and cognitive test features are most useful for making this distinction?

Researchers will compare speech recordings and cognitive test results from patients diagnosed with dementia or MCI to those from patients with normal cognition or non-neurodegenerative cognitive impairment to see if the AI model can reliably predict who needs specialist dementia care.

Participants will:

Complete standard cognitive tests at the memory clinic Perform structured speech tasks while being audio-recorded Receive their usual clinical evaluation and diagnosis from memory clinic specialists

The results of this study will help develop a tool that can assist doctors in making faster, more accurate decisions about which patients need specialist dementia evaluation, potentially leading to earlier diagnosis and better patient outcomes.

Inclusion: Model A (patient participants); Age > 50 years; Fluent in Danish; Minimum of 7 years of schooling; A diagnosis of either MCI or AD, given at the SUH memory clinic within 6 months before enrollment; Model A (cognitively healthy controls); Age > 50 years; Fluent in Danish; Minimum of 7 years of schooling; Model B:; Age > 50 years; Fluent in Danish; Minimum of 7 years of schooling.

Exclusion: Concomitant diagnoses which are expected to influence cognitive impairment (eg. depression); Patients with concomitant psychosis or severe psychiatric comorbidities other than depression; Any history of speech or language impairment predating the current condition; Cognitively healthy controls:; Known diseases which are expected to impair cognitive functions; Any history of speech or language impairment predating the current condition; Any history of speech or language impairment predating the current condition; Clinical, laboratory, or neuroradiological findings that could affect cognitive functions; Model A:; Patients:; Significantly impaired vision or hearing (to the extent that the patient cannot participate in the AI analysis); MMSE score < 16; Patients unable to give consent; Patients with alcohol consumption >21 standard alcohol units per week; Significantly impaired vision or hearing (to the extent that the patient cannot participate in the AI analysis); MMSE < 26 and ACE < 90; Patients with alcohol consumption >21 standard alcohol units per week; Model B:; Significantly impaired vision or hearing (to the extent that the patient cannot participate in the AI analysis); MMSE score < 16; Patients unable to give consent.

ClinicalTrials.gov NCT07200739