Tests infection prevention treatments in people with blood cancers
Compares ways to prevent infection in adults with blood cancers.
Plain-language title generated from the registry record
Registry title: Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy: Starting Immunoglobulin (Start Ig)
Key facts
- Where
- Adelaide and Melbourne, AustraliaSee the 3 sites
- Phase
- Phase 2/3
Where in Australia
- Royal Adelaide HospitalAdelaide, AustraliaTaking people
- Austin HospitalMelbourne, AustraliaTaking people
- Northern HealthMelbourne, AustraliaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Monash University
- Trial code
- NCT07202078
- Record updated
- 7 October 2025
- Original description
This study is being conducted to find out how safe and effective different strategies of infection prevention are in comparison to each other, for preventing infection in patients with blood cancers. The best way to find out this information is to directly compare the effect of different treatment strategies in patients with blood cancers. We want to know how these different treatments impact on your health and your use of healthcare services.Read full original descriptionShow less
Role of Antibiotic Therapy or Immunoglobulin On iNfections in hAematoLogy (Start Ig)
This study is being conducted to find out how safe and effective different strategies of infection prevention are in comparison to each other, for preventing infection in patients with blood cancers. The best way to find out this information is to directly compare the effect of different treatment strategies in patients with blood cancers. We want to know how these different treatments impact on your health and your use of healthcare services.
This research project uses an Adaptive Platform Design. This design allows the researchers to compare multiple infection prevention strategies within the same trial at the same time (rather than running separate trials), to analyse results as the trial occurs and to add new research questions during the course of the trial.
The treatments that you may receive as part of the study will be determined by which domain(s) of the platform you participate in. By combining data collected within each domain as part of the platform, the researchers can investigate and compare treatment strategies and infection outcomes across a broader range of participants.
Inclusion: None.
Exclusion: Prior or planned allogeneic haematopoietic stem cell transplantation; Already receiving systemic antibiotic prophylaxis for the purpose of preventing bacterial infection (NB: patients may receive antiviral, antifungal and PJP prophylaxis); Received immunoglobulin replacement in the preceding three months; Objection to receiving immunoglobulin products; Previous splenectomy; Previous participation in this domain; Known history of IgA deficiency with anti-IgA; History of severe allergy to immunoglobulin products; Current active infection requiring systemic antibiotics; Allergy or intolerance of all domain antibiotic options; Severe renal impairment (estimated or measured creatinine clearance of < 30 mL/min); Pregnant or breastfeeding; Treating team deems enrolment in the domain is not in the best interest of the patient.