Tests whether chemotherapy before surgery affects bladder cancer MRI scans
Compares MRI accuracy in bladder cancer patients given chemotherapy before surgery versus surgery alone.
Plain-language title generated from the registry record
Registry title: Effect of Neoadjuvant Chemotherapy on MRI Accuracy Before Cystectomy
Key facts
- Where
- Asyut, EgyptSee the site
Where in Egypt
- Urology Department, Faculty of Medicine, Assiut UniversityAsyut, EgyptNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Assiut University
- Trial code
- NCT07202819
- Record updated
- 2 October 2025
- Original description
The goal of this clinical trial is to learn if neoadjuvant chemotherapy (NAC) affects the accuracy of magnetic resonance imaging (MRI) in staging muscle-invasive bladder cancer (MIBC). This study will also assess how tissue changes induced by NAC impact MRI interpretation. The main questions it aims to answer are:Read full original descriptionShow less
Does Neoadjuvant Chemotherapy Affect the Accuracy of Magnetic Resonance Imaging Before Radical Cystectomy? A Randomized Controlled Trial.
The goal of this clinical trial is to learn if neoadjuvant chemotherapy (NAC) affects the accuracy of magnetic resonance imaging (MRI) in staging muscle-invasive bladder cancer (MIBC). This study will also assess how tissue changes induced by NAC impact MRI interpretation. The main questions it aims to answer are:
Does NAC compromise the accuracy of MRI in staging MIBC?
Does NAC-induced tissue change affect the reliability of MRI in tumor assessment?
Researchers will compare MRI staging accuracy in MIBC patients who received NAC to those who went directly to surgery, to see if NAC impacts MRI's diagnostic performance.
Participants will:
Undergo MRI scanning before surgery
Receive either NAC or go directly to surgery, depending on their group assignment
Have their MRI results compared to histopathological outcomes after surgery
Inclusion: Patients diagnosed with cT2 urothelial carcinoma of the urinary bladder, according to the TNM classification, who give informed, written consent on participation in the study and approve all its requirements.
Exclusion: Patients who have received pelvic radiotherapy; Previous open or laparoscopic pelvic surgery; Patients with contraindications to MRI; Patients who are unfit for or refuse radical cystectomy; Ineligibility to cisplatin; squamous differentiation in the histopathology.