Checks liver imaging tests against liver biopsy in children with liver disease
Tests imaging methods for liver scarring and fat in children with liver disease.
Plain-language title generated from the registry record
Registry title: VALidation of Imaging-based Liver Biomarkers in PEDiatric Patients
Key facts
- Where
- Gothenburg, SwedenSee the site
Where in Sweden
- Department of Radiology, Queen Silvias Children´s Hospital,Gothenburg SwedenGothenburg, SwedenTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Sahlgrenska University Hospital
- Trial code
- NCT07202910
- Record updated
- 2 October 2025
- Original description
The goal of this observational (diagnostic validation) study is to validate imaging-based biomarkers for assessing liver involvement in pediatric patients with established or suspected liver disease. The projekt involves 3 larger studies, each with specific aims specified in detailed description below.Read full original descriptionShow less
Imaging-Based Biomarkers for Non-Invasive Pediatric Liver Diagnostics
The goal of this observational (diagnostic validation) study is to validate imaging-based biomarkers for assessing liver involvement in pediatric patients with established or suspected liver disease. The projekt involves 3 larger studies, each with specific aims specified in detailed description below.
The main study (study 1) compares imaging-based biomarkers-with liver biopsy to evaluate their correlation with histologically confirmed liver disease, including fibrosis, inflammation, and steatosis. The main question the overall project aims to answer is:
• Can multiple novel imaging-based biomarkers, such as shear wave elastography (SWE), shear wave dispersion (SWD), and attenuation imaging (ATI), be used for detailed, non-invasive liver characterization in children, and if so, how should they be used?
Inclusion: all patients scheduled for a clinically liver biopsy at the Queen Silvia Children's Hospital; any form of suspected or confirmed liver disease; age between 0-18 years; consent by the child/parents to participate; For controls: children scheduled for a renal biopsy; age between 0-18 years; consent by the child/parents to participate.
Exclusion: technical limitations regarding the measurements; inability to fully understand the informed consent documents.