NCT07207551Completed
Prevalence of Hemoglobinopathies Associated With Significant Hb Variants in the Chattogram Region of Bangladesh
Prevalence of Hb Variants and Haemoglobinopathies in a Tertiary Care Hospital: A Retrospective Cross-sectional Study
Source: ClinicalTrials.gov · Last updated 6 Oct 2025
Brief summary (registry, in English)
Hemoglobinopathies represent a collection of genetic conditions that influence the structure or synthesis of haemoglobin, the protein found in red blood cells that facilitates oxygen transport from the lungs throughout the body. This research proposal presents a study evaluating the prevalence of hemoglobinopathies and their significant haemoglobin variants within a specific population. The research will employ a cross-sectional study design, recruiting participants through community outreach efforts and healthcare facilities while obtaining informed consent. Data will be collected with the utmost precision and rigor, using advanced screening techniques such as high-performance liquid chromatography (HPLC), capillary electrophoresis, and molecular analysis. The gathered data will be processed to assess haematological parameters, including RBC, Iron Ferritin, TIBC, electrophoresis profiles (HbA, HbA2, HbE, HbF), MCV, MCHC, and PCV among individuals with hemoglobinopathies (HbE disease/trait, Beta thalassemia disease/trait, heterozygous HPFH, HbE-beta thal). They will examine variations relative to demographic factors. The expected results will have substantial clinical and public health consequences by enhancing genetic counselling, informing clinical decision-making, and strengthening public health initiatives.
- Status (registry)
- Completed
- Study type
- Observational
- Enrollment
- 760 (actual)
- First submitted
- 14 Sept 2025
- Start date
- 1 Jun 2023
- Primary completion date
- 17 Jun 2025
- Lead sponsor
- Bangladesh Bioscience Research Group
- Diseases
- Thalassaemia
- NCT number
- NCT07207551
What you commit to
- Study type: Observational
- Participants enrolled: 760
- From 1 Jun 2023 to the primary completion date, 17 Jun 2025
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Other
- Refusal or withdrawal of consent.
- Blood transfusion within the last 3 months.
- Pregnant women.
- Inadequate or hemolyzed blood samples.
Who the study is looking for
- Residents of the Chattogram metropolitan area.
- All ages and both sexes with informed consent.
- Willing to provide venous blood samples.
- No blood transfusion in the past 3 months.
Sex: All · Does not accept healthy volunteers
Sites (1)
Sites in registry order. Pick your city on the disease page to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| University of Science and Technology Chittagong (USTC) Coordinator of this site? Confirm its status | Khulshi | Bangladesh | Unknown status |
This page is information, not medical advice. Discuss any trial with your doctor.