NCT07207577Recruiting
Evaluation of Physiological and Psychological Factors Involved in Exercise Intolerance in Patients With β-TTD
Evaluation of Physiological and Psychological Factors Involved in Exercise Intolerance in Patients With Transfusion-dependent β-thalassemia
Source: ClinicalTrials.gov · Last updated 7 Oct 2026
Brief summary (registry, in English)
The goal of this clinical trial is to compare physical ability of patients with transfusion-dependent β-thalassemia to control subjects. The main question it aims to answer is: is there a difference in power output at first lactate threshold between patients with transfusion-dependent β-thalassemia and control subjects during maximal incremental exercise test. Participants will have to realise differents exams including measurement of body compposition, maximal incremental exercise test, vertical jump, vasoreactivity test, blood sampling, quality of life questionnaires and neuromuscular assessments.
- Status (registry)
- Recruiting
- Study type
- Interventional
- Enrollment
- 36 (estimated)
- First submitted
- 16 Sept 2025
- Start date
- 4 Sept 2025
- Primary completion date
- Oct 2028
- Lead sponsor
- Centre Hospitalier Metropole Savoie
- Diseases
- Thalassaemia
- NCT number
- NCT07207577
What you commit to
- Study type: Interventional
- Planned participants: 36
- From 4 Sept 2025 to the primary completion date, Oct 2028
- 1 site in 1 country
- Visits and tests: ask the trial team, the registry does not list them
Built from the registry fields of ClinicalTrials.gov. It describes the study, not your situation.
Who cannot take part
Copied verbatim from ClinicalTrials.gov and grouped by topic. Only the trial team decides who can take part.
Prior treatment
- \- Having received a bone marrow transplant.
- Known concomitant medical condition that could affect compliance with the protocol
Other illness
- History of thromboembolic disease.
- Hospitalised for cardiac decompensation in the last 12 months.
Other
- Lack of use of limbs (amputee, paraplegic, quadriplegic)
- Unable to comply with protocol requirements for social, family or other reasons, as determined by the investigator.
- benefiting of enhanced protection, namely minors, persons deprived of their liberty by judicial or administrative decision, adults under legal protection and, finally, patients in emergency situations.
- Unable to give consent.
- Pregnant or breastfeeding women.
Who the study is looking for
- Patients aged 18 years or older
- Patients with transfusion-dependent β-thalassaemia (B0 or B+)
- Patients who have undergone blood transfusions at intervals of between 1 and 8 weeks for at least 5 years.
- Have given their free and informed written consent after being informed of the purpose of the study, its conduct and its risks.
- Be affiliated with a social security scheme.
- Not participating in any other interventional studies during the duration of this study
- Control subjects must meet all of the following criteria to participate in the study:
- Subject aged 18 years or older
- Matched in age and gender to a βTTD patient included in the study.
- Declaring to be free of known acute or chronic pathologies.
- Have given their free written consent after being informed of the purpose of the study, its conduct and its risks.
- Be affiliated with a social security scheme.
- Not participate in any other interventional study during the duration of this study.
- Have 'low' or 'moderate' IPAQ results (inactive or slightly active).
Age in the registry: 18 years to - · Sex: All · Accepts healthy volunteers
Sites (1)
Sites in registry order. Save your city in your profile to sort them by distance.
| Site | City | Country | Site status |
|---|---|---|---|
| CH Métropole-Savoie Coordinator of this site? Confirm its status | Chambéry | France | Recruiting |
This page is information, not medical advice. Discuss any trial with your doctor.