Tests a device to prevent leaks after colon cancer surgery
Tests endoscopic vacuum therapy to prevent leaks in adults after colorectal cancer surgery.
Plain-language title generated from the registry record
Registry title: Pre-emptive Endoscopic Vacuum Therapy Reduces the Incidence of Anastomotic Leakage After Colorectal Cancer Surgery
Key facts
- Where
- Nanchong, ChinaSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 85 years old?
Source: NCT07208786, who can take part
Where in China
- Nanchong Central HospitalNanchong, ChinaTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Nanchong Central Hospital
- Trial code
- NCT07208786
- Record updated
- 2 November 2026
- Original description
Evaluate the safety and efficacy of postoperative Pre-emptive EVT (PEVT) in reducing the incidence of anastomotic leaks within 30 days after surgery in patients with colorectal cancer. Compare the differences between the PEVT group and the control group in terms of operation time, length of hospital stay, and total medical costs. Analyze the incidence of other postoperative complications in the two groups, such as wound infection, abdominal abscess, and intestinal obstruction. Assess the impact of PEVT on postoperative recovery indicators, including time to first flatus, time to first defecation, and time to ambulation. Observe the occurrence of PEVT-related adverse events, such as device displacement, bleeding, and infection.Read full original descriptionShow less
Randomized Clinical Trial on Pre-emptive Endoscopic Vacuum Therapy Versus Conventional Management for the Prevention of Anastomotic Leakage After Colorectal Cancer Surgery
Evaluate the safety and efficacy of postoperative Pre-emptive EVT (PEVT) in reducing the incidence of anastomotic leaks within 30 days after surgery in patients with colorectal cancer. Compare the differences between the PEVT group and the control group in terms of operation time, length of hospital stay, and total medical costs. Analyze the incidence of other postoperative complications in the two groups, such as wound infection, abdominal abscess, and intestinal obstruction. Assess the impact of PEVT on postoperative recovery indicators, including time to first flatus, time to first defecation, and time to ambulation. Observe the occurrence of PEVT-related adverse events, such as device displacement, bleeding, and infection.
Inclusion: Pathologically diagnosed with colorectal cancer, planned for radical surgery (right hemicolectomy, left hemicolectomy, or anterior resection of the rectum, etc.); Age 18-85 years, American Society of Anesthesiologists (ASA) classification I-III; Anastomosis to be performed in a single stage (meeting anastomotic criteria); Patient or legal guardian is able to understand and sign the informed consent form and comply with follow-up.
Exclusion: Preexisting anastomotic leakage or severe intra-abdominal infection before surgery; Complicated by severe cardiovascular or cerebrovascular diseases (e.g., acute myocardial infarction, acute phase of cerebral infarction); History of abdominal radiotherapy or multiple abdominal surgeries leading to severe intra-abdominal adhesions; Complicated by other malignant tumors and currently undergoing radiotherapy or chemotherapy; Psychiatric illness or cognitive impairment preventing compliance with the study; Severe liver or kidney dysfunction (liver function Child-Pugh class C, creatinine clearance <30 ml/min); Coagulation disorders (platelets <50×10⁹/L, INR >1.5) or receiving anticoagulant therapy that cannot be adjusted.