Home-Based Strategies for Knee Osteoarthritis
Key facts
- Who runs it
- Istanbul University - Cerrahpasa
- Where
- Türkiye2 sites in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 83 people enrolled
- Started
- 9 Oct 2025
- Ended
- 26 Feb 2026
- Type of study
- Interventional, 2 groupsOne group gets an existing treatment, for comparison.
- Treatments tested
- Home Exercise Group
- Topical Therapy Group
- Record updated
- 27 February 2026
Who can take part
- Age
- 40 years to 70 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 8 criteriaShow less
Who can take part
- Adults aged 40-70 years
- Diagnosed with Kellgren-Lawrence grade I-II knee osteoarthritis
- Ability to provide written informed consent
Who cannot take part
- Prior knee surgery within the past year
- Neurological, rheumatological, or systemic conditions affecting mobility
- Advanced KOA (Kellgren-Lawrence grade IV) requiring arthroplasty
- Intra-articular injections within the last 3 months
- Inability to comply with study procedures
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Knee osteoarthritis (KOA) is a common chronic joint condition leading to pain, functional limitations, and reduced quality of life. This randomized controlled trial aims to evaluate and compare the effectiveness of a structured home-based exercise program versus topical diclofenac sodium therapy in improving pain, functional outcomes, and health-related quality of life among adults with early-stage KOA. The results are intended to provide evidence on the optimal components of home-based conservative management strategies.
The 2 groups in the trial
- Home Exercise GroupTreatment being tested
Each subject in the home exercise group will receive a video-based protocol of exercises for knee osteoarthritis to perform at home.
- Topical Therapy GroupExisting treatment, for comparison
Each subject in the topical therapy group will apply topical gel to anterior, medial, and lateral aspects of the knee at home.
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Home-Based Strategies for Knee Osteoarthritis: Comparative Effectiveness of Exercise and Topical Therapy in a Randomized Controlled Trial
- Record updated
- 27 February 2026