Tests high-dose dexamethasone to ease pain after lung surgery
Tests high-dose dexamethasone for postoperative pain in adults having lung surgery.
Plain-language title generated from the registry record
Registry title: High Dose Dexamethasone to Reduce Postoperative Pain After Video-Assisted Thoracoscopic Surgery Lobectomy /Segmentectomy
Key facts
- Where
- Copenhagen Oe, DenmarkSee the site
- Phase
- Phase 2/3
Where in Denmark
- RigshospitaletCopenhagen Oe, DenmarkTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Copenhagen University Hospital, Rigshospitalet
- Trial code
- NCT07213375EU 2025-520891-25-00
- Record updated
- 7 January 2026
- Original description
The aim is to conduct a randomized controlled trial (RCT) with a high dose arm (1mg/kg) vs a low dose (8mg in total) of steroid (Dexamethasone) given intravenous (IV) after the induction of anesthesia to "High-pain-responders" in patients undergoing VATS lobectomy/segmentectomy.Read full original descriptionShow less
High Dose Dexamethasone In High-Pain Responders Undergoing Enhanced Recovery Video-Assisted Thoracoscopic Surgery Lobectomy and Segmentectomy - A Randomized Double-Blinded Controlled Trial
The aim is to conduct a randomized controlled trial (RCT) with a high dose arm (1mg/kg) vs a low dose (8mg in total) of steroid (Dexamethasone) given intravenous (IV) after the induction of anesthesia to "High-pain-responders" in patients undergoing VATS lobectomy/segmentectomy.
The hypothesis is that a high dose of Dexamethasone can lower pain when coughing in the morning after VATS lobectomy/segmentectomy, in patients scoring as "High-pain-responders" on the Pain-Catastrophizing-Scale
Inclusion: Age ≥ 18 year; Able to understand written and spoken Danish language; PCS ≥20; Signed written informed consent form; Patient planned to elective VATS lobectomy/segmentectomy.
Exclusion: Patients undergoing systemic glucocorticoid or other immunosuppressive therapies, ex-cluding inhaled steroids; Individuals with diabetes requiring insulin treatment; Pregnant or breastfeeding patients; Patients with known allergies to the study drug; Individuals with mental disabilities that may impair their capacity to provide informed consent or compromise the validity of data collection; Patients with diagnosed schizophrenia, active psychosis, bipolar disorder, or a history of ongoing treatment with antipsychotic and/or antidepressant medications; Individuals with altered pain perception due to other conditions or injuries, such as spi-nal cord or brain injuries, severe polyneuropathies, or neurological disorders; Regular users of opioid medications; Patients requiring reoperation within the first two postoperative days; Individuals undergoing conversion to a surgical procedure other than VATS lobecto-my/segmentectomy.