K08 VR Fear Conditioning
Key facts
- Who runs it
- University of California, Los Angeles
- Where
- Los Angeles, United StatesSee the site
- Trial code
- Status
- Recruiting
- People taking part
- 70 people, planned
- Started
- 1 Mar 2025
- Expected to end
- 28 Feb 2030
- Type of study
- Interventional
- Treatments tested
- Deep Brain Stimulation
- Record updated
- 13 October 2026
Who can take part
- Age
- 18 years to 70 years
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
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Who can take part
- Male
- Female
- Between 18 and 70 years of age
- Adequate visual and auditory acuity to allow neuropsychological testing
- Have undergone surgical placement of NeuroPace RNS System for the treatment of epilepsy or post-traumatic stress disorder
Who cannot take part
- History of traumatic brain injury
Check if you might fit
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 70 years old?
Where in United States
- UCLA Semel Institute for Neuroscience and Human BehaviorLos Angeles, United StatesContact: Anthony I Jang, MDTaking people
About the trial
What the trial wants to find out
The goal of this clinical trial is to learn how people respond to fear-related experiences in a virtual reality (VR) environment. The study will also look at how brain activity and body responses are connected to learning and memory of fear. To do so, we recruit individuals who are already implanted with a Responsive Neurostimulator (RNS) device for the treatment of epilepsy. This research may help improve our understanding of anxiety disorders and how to better treat them in the future.
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The main questions it aims to answer are: 1) How do people learn to associate certain cues in VR with feelings of fear or safety? 2) What brain and body responses happen during fear learning?
Participants will: 1) Wear a virtual reality headset and experience different environments and sounds, 2) Have their brain activity, heart rate, and sweating measured, and 3) Receive safe, mild electrical pulses through the RNS device during the study to help study fear learning. Participants will attend one or more study sessions, each lasting about 3-4 hours.
The group in the trial
- All RNS ParticipantsTreatment being tested
In this single-arm study, all participants will complete identical experimental conditions with simultaneous iEEG recordings (Recording Study) or iEEG stimulation (Stimulation Study).
Treatment: Deep Brain Stimulation
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Intracranial Recording and Stimulation of the Human Hippocampal-Amygdala Circuit During Virtual Reality Fear Conditioning
- Fit questions
- Built from NCT07216222, who can take part
- Record updated
- 13 October 2026