Testing baricitinib to protect insulin-making cells in new type 1 diabetes
Tests baricitinib against placebo in people newly diagnosed with type 1 diabetes.
Plain-language title generated from the registry record
Registry title: A Study of Baricitinib (LY3009104) to Preserve Beta Cell Function in Children and Adults Newly Diagnosed With Type 1 Diabetes (BARICADE-PRESERVE)
Key facts
- Where
- Campo Grande, Curitiba, Fortaleza, Goiânia, Marília, Porto Alegre, Ribeirão Preto, Rio de Janeiro, São Paulo, and Vitória, BrazilSee the 15 sites
- Phase
- Phase 3
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 1 and 35 years old?
Source: NCT07222332, who can take part
Where in Brazil
- Hospital Universitário Maria Aparecida PedrossianCampo Grande, BrazilTaking people
- Centro de Diabetes CuritibaCuritiba, BrazilTaking people
- Quanta Diagnóstico e TerapiaCuritiba, BrazilTaking people
- Centro De Diabetes Metabolismo E EndocrinologiaFortaleza, BrazilTaking people
- Cendi - Endocrinologia e DiabetesGoiânia, BrazilTaking people
- Centro de Pesquisa Clínica de Marília - CPCLIMMarília, BrazilTaking people
- Instituto da Crianca com DiabetesPorto Alegre, BrazilTaking people
- Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo (USP) - HCFM -TRibeirão Preto, BrazilTaking people
- Universidade Federal Do Rio de JaneiroRio de Janeiro, BrazilTaking people
- Clínica Hepatogastro JKSão Paulo, BrazilTaking people
- CPCLINSão Paulo, BrazilTaking people
- Hospital das Clinicas FMUSPSão Paulo, BrazilTaking people
- IBTED - Tecnologia e Educação em DiabetesSão Paulo, BrazilTaking people
- Instituto de Pesquisa ClinicaSão Paulo, BrazilTaking people
- CEDOESVitória, BrazilTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Eli Lilly and Company
- Trial code
- NCT07222332EU 2025-522170-36-00
- Record updated
- 4 November 2026
- Original description
The purpose of this study is to find out if baricitinib can preserve beta-cell function in participants newly diagnosed with type 1 diabetes. Participation in the study will last about 60 weeks.Read full original descriptionShow less
A Phase 3, Double-Blind, Randomized, Placebo-Controlled Study of Baricitinib to Preserve Beta Cell Function in Participants Newly Diagnosed With Type 1 Diabetes Aged ≥1 to <36 Years
The purpose of this study is to find out if baricitinib can preserve beta-cell function in participants newly diagnosed with type 1 diabetes. Participation in the study will last about 60 weeks.
Inclusion: Have a new diagnosis of type 1 diabetes within 100 days prior to starting study intervention; Have at least one diabetes-related autoantibody found at screening; Show signs of remaining beta-cell function; stimulated (peak or 90 min) C-peptide ≥0.2 nmol/L (0.6 ng/mL) at screening; Weigh at least 8 kilograms (kg) (18 pounds) at screening.
Exclusion: Have any other type of diabetes including gestational; Have had a heart attack, heart disease, stroke, or heart failure; Have a history or high risk of venous thromboembolism, lymphoproliferative disease or malignancy; Have a current or recent clinically serious medical condition or infection; Have uncontrolled high blood pressure.