Testing baricitinib to protect insulin-making cells in new type 1 diabetes
Tests baricitinib against placebo in people newly diagnosed with type 1 diabetes.
Plain-language title generated from the registry record
Registry title: A Study of Baricitinib (LY3009104) to Preserve Beta Cell Function in Children and Adults Newly Diagnosed With Type 1 Diabetes (BARICADE-PRESERVE)
Key facts
- Where
- Beer Yaacov, Beersheba, Haifa, Herzliya, Jerusalem, Kfar Saba, Petah Tikva, Ramat Gan, and Tel Aviv, IsraelSee the 11 sites
- Phase
- Phase 3
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 1 and 35 years old?
Source: NCT07222332, who can take part
Where in Israel
- Yitzhak Shamir Medical CenterBeer Yaacov, IsraelTaking people
- Soroka Medical CenterBeersheba, IsraelTaking people
- Rambam Health Care CampusHaifa, IsraelTaking people
- Linn Medical CenterHaifa, IsraelNo longer taking part
- Institute of Diabetes, Technology and Research - Clalit HealthHerzliya, IsraelNo longer taking part
- Hadassah medical CenterJerusalem, IsraelNo longer taking part
- Meir Medical CenterKfar Saba, IsraelTaking people
- Schneider Children's Medical CenterPetah Tikva, IsraelTaking people
- Rabin Medical CenterPetah Tikva, IsraelNo longer taking part
- Sheba medical centerRamat Gan, IsraelNo longer taking part
- Sourasky Medical CenterTel Aviv, IsraelTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Eli Lilly and Company
- Trial code
- NCT07222332EU 2025-522170-36-00
- Record updated
- 4 November 2026
- Original description
The purpose of this study is to find out if baricitinib can preserve beta-cell function in participants newly diagnosed with type 1 diabetes. Participation in the study will last about 60 weeks.Read full original descriptionShow less
A Phase 3, Double-Blind, Randomized, Placebo-Controlled Study of Baricitinib to Preserve Beta Cell Function in Participants Newly Diagnosed With Type 1 Diabetes Aged ≥1 to <36 Years
The purpose of this study is to find out if baricitinib can preserve beta-cell function in participants newly diagnosed with type 1 diabetes. Participation in the study will last about 60 weeks.
Inclusion: Have a new diagnosis of type 1 diabetes within 100 days prior to starting study intervention; Have at least one diabetes-related autoantibody found at screening; Show signs of remaining beta-cell function; stimulated (peak or 90 min) C-peptide ≥0.2 nmol/L (0.6 ng/mL) at screening; Weigh at least 8 kilograms (kg) (18 pounds) at screening.
Exclusion: Have any other type of diabetes including gestational; Have had a heart attack, heart disease, stroke, or heart failure; Have a history or high risk of venous thromboembolism, lymphoproliferative disease or malignancy; Have a current or recent clinically serious medical condition or infection; Have uncontrolled high blood pressure.