Studying brain activity in the hippocampus during visual exploration and walking
Studies brain activity in the hippocampus during looking and moving in people with epilepsy.
Plain-language title generated from the registry record
Registry title: Hippocampal Oscillations During Exploration
Key facts
- Where
- New York, United StatesSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 70 years old?
Source: NCT07224191, who can take part
Where in United States
- NYU Langone HealthNew York, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- NYU Langone Health
- Trial code
- NCT07224191
- Record updated
- 8 July 2026
- Original description
The objective of this study is to determine how visuomotor exploration relates to hippocampal activity along its long axis. The study will investigate the neurophysiological mechanisms in the hippocampus during (1) visual exploration in surgical patients using high-resolution iEEG, and (2) ambulatory exploration in patients implanted with RNS devices.Read full original descriptionShow less
Human Hippocampal Oscillations During Visuomotor Exploration
The objective of this study is to determine how visuomotor exploration relates to hippocampal activity along its long axis. The study will investigate the neurophysiological mechanisms in the hippocampus during (1) visual exploration in surgical patients using high-resolution iEEG, and (2) ambulatory exploration in patients implanted with RNS devices.
Inclusion: All subjects:; Adults (18-70 years); Able to provide informed consent; Aim 1: Surgical epilepsy patients' inclusion criteria; Implanted hippocampal depth electrodes for Stage 1 epilepsy surgery; MMSE>=24; Aim 2: RNS patients Inclusion criteria; Implanted RNS device with at least one hippocampal depth electrode; At least 5 months post-implantation to avoid the post-implant effect; Have a relatively low number of seizures, defined as <1 generalized tonic-clonic or other seizure with potential to fall or cause injury per month; Able to walk and wear research equipment without assistance; MMSE>=24; Aim 2: Healthy Control Inclusion criteria • Able to walk and wear research equipment without assistance.
Exclusion: Smoking tobacco, marijuana, recreational drugs or alcohol use within 1 week of cognitive testing; Any generalized tonic-clonic seizure within the last week; All subjects:; RNS patients, Aim 2:; Legally blind; Unable to give informed consent; Pregnancy.