Impact of Intraoperative Oxygenation Practices on Patient Outcomes
Key facts
- Where
- Ann Arbor, Nashville, Omaha, and Salt Lake City, United StatesSee the 4 sites
Where in United States
- University of Michigan HospitalAnn Arbor, United StatesTaking people
- Vanderbilt University Medical CenterNashville, United StatesTaking people
- Nebraska Medical CenterOmaha, United StatesTaking people
- University of Utah - Huntsman Cancer InstituteSalt Lake City, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Frederic T Billings IV
- Trial code
- NCT07224243
- Record updated
- 16 September 2026
- Original description
This multicenter, cluster-randomized, cluster-crossover clinical trial evaluates the impact of three intraoperative FiO2 (Fraction of Inspired Oxygen) oxygenation strategies-lower (FiO₂ 0.21-0.40), intermediate (FiO₂ 0.40-0.80), and higher (FiO₂ 0.80-1.00)-on postoperative organ injury and mortality in adult surgical patients. The trial aims to determine the optimal oxygenation strategy to improve perioperative outcomes.Read full original descriptionShow less
This multicenter, cluster-randomized, cluster-crossover clinical trial evaluates the impact of three intraoperative FiO2 (Fraction of Inspired Oxygen) oxygenation strategies-lower (FiO₂ 0.21-0.40), intermediate (FiO₂ 0.40-0.80), and higher (FiO₂ 0.80-1.00)-on postoperative organ injury and mortality in adult surgical patients. The trial aims to determine the optimal oxygenation strategy to improve perioperative outcomes.
Inclusion: Patient located in a participating operating room; Planned surgery includes tracheal intubation.
Exclusion: Patient's planned procedure requires prolonged apnea, bronchoscopy, airway surgery, or one-lung ventilation; Patient's planned surgical case includes use of extracorporeal membrane oxygenation (ECMO); Patient was enrolled in the trial in the prior 30 days; Patient's planned surgical case includes open heart surgery, defined as surgery on the heart or ascending aorta requiring sternotomy or thoracotomy; Patient is known to have a history of bleomycin treatment; Patient is known to be less than 18 years old; Patient is known to be pregnant; Patient is known to be a prisoner; Patient is American Society of Anesthesiologists (ASA) classification-6 (i.e., organ donor).