Meaning-based talk therapy for Mexican adults living with advanced cancer

Trial details

Who runs it

Memorial Sloan Kettering Cancer Center

Trial code

NCT07225309

Record updated

3 August 2026

Original description

The purpose of this study is to find out if Meaning-Centered Psychotherapy for Latinos (MCP-L) helps reduce anxiety and depression and improves quality of life compared to cognitive behavioral therapy (CBT). Investigators also want to learn what participants and providers think about the therapy, including how the therapy is designed, outside factors, available resources, and how the people involved affect how well MCP-L works.Read full original descriptionShow less

Trial of Meaning Centered Psychotherapy for Mexican Patients With Advanced Cancer

The purpose of this study is to find out if Meaning-Centered Psychotherapy for Latinos (MCP-L) helps reduce anxiety and depression and improves quality of life compared to cognitive behavioral therapy (CBT). Investigators also want to learn what participants and providers think about the therapy, including how the therapy is designed, outside factors, available resources, and how the people involved affect how well MCP-L works.

Inclusion: EMR Criteria; Documentation of Disease; Pathologically confirmed breast, prostate, colorectal, thyroid, cervix, uteri, or lung - solid tumor cancer (either most recent or new diagnosis); Definition of Disease [or Measurable Disease]; Diagnosed with stages III or IV; Prior Treatment; Receiving ambulatory care at INCan; Self-Report Criteria; Age ≥ 18 years; Able to read and communicate in Spanish determined by the question: "Can you read and communicate in Spanish? Yes/No"; Professional role of administrators, clinicians (e.g., oncologists), mental health providers, supervised therapists-in-training (e.g., graduate students), or other related provider delivering the MCP-L experimental intervention; Providing care (or services) to Mexican cancer patients at INCan; Has access to internet and an electronic device; Agrees to be audio-recorded; Age ≥ 18 years; Able to read and communicate in Spanish determined by the question: "Can you read and communicate in Spanish? Yes/No"; Professional role of administrators, clinicians (e.g., oncologists), mental health providers, supervised therapists-in-training (e.g., graduate students), or other related provider delivering the MCP-L experimental intervention; Providing care (or services) to Mexican cancer patients at INCan; Has access to internet and an electronic device; Agrees to be audio-recorded.

Exclusion: Prior Treatment; Received psychological or psychiatric care at INCan in the last 3 months; In the judgment of the treating physician, protocol investigators, and/or study staff, presence of cognitive impairment (e.g., delirium or dementia) sufficient to preclude meaningful informed consent and/or study participation; Diagnosed with a serious psychiatric condition; Self-Report Criteria; Received psychological or psychiatric care outside of INCan in the last 3 months; EMR Criteria; Presence of suicide risk determined by the Columbia-Suicide Severity Rating Scale; Too ill to participate determined by the question: "Do you feel too ill to participate because of communication problems, uncontrollable pain, or other symptoms that prevent you from participating?"; Provider Eligibility Criteria:.

Patient Eligibility Criteria:; A patient cannot be considered eligible for this study unless ALL of the following conditions are met. Participant eligibility will be determined by an initial EMR review followed by a self-report screener and suicide risk assessment.

ClinicalTrials.gov NCT07225309