Frontlight ResearchEarly access
TerminatedPhase 2
Sex Differences in Neurobehavioral Response to THC
Key facts
- Who runs it
- Medical University of South Carolina
- Where
- Charleston, United StatesSee the site
- Trial code
- Status
- Terminated
- Phase
- Phase 2
- People taking part
- 5 people enrolled
- Started
- 27 Apr 2026
- Ended
- 31 Aug 2026
- Type of study
- Interventional, 2 groups
- Treatments tested
- Dronabinol
- Placebo
- Record updated
- 6 October 2026
- Why it stopped
- Funding status change.
Who can take part
- Age
- 21 years to 45 years
- Sex
- Women and men
- Healthy volunteers
- Cannot take part
The registry criteria, word for word
Show all 14 criteriaShow less
Who can take part
- Age 21-45
- DSM-5 criteria for CUD
- Cannabis use ≥4 days/week
- THC-positive urine
- BMI 18-30
- Regular menstrual cycle (females)
- Willingness to use non-hormonal birth control (females)
Who cannot take part
- Recent drug use other than cannabis
- Current psychotropic medication
- Lifetime psychotic or bipolar disorder
- Current psychiatric disorder (except mild alcohol, nicotine, or caffeine use disorder)
- Treatment-seeking for SUD
- Pregnancy/nursing
- MRI contraindications
Where in United States
- Medical University of South CarolinaCharleston, United States
About the trial
What the trial wants to find out
This study investigates sex differences in reward processing following acute THC administration in adults with cannabis use disorder (CUD). Using multimodal neuroimaging (MRS and fMRI), the study will assess glutamate levels in the nucleus accumbens and striatal BOLD response to monetary reward anticipation. Participants will complete two counterbalanced dosing sessions (oral THC 40 mg vs. placebo).
The 2 groups in the trial
- MalesOther group
Treatment: Dronabinol and Placebo
- FemalesOther group
Treatment: Dronabinol and Placebo
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Sex Differences in Neurobehavioral Response to Acute THC in Adults With Cannabis Use Disorder
- Record updated
- 6 October 2026