Tests coaching before brain training for memory problems in multiple sclerosis
Tests coaching before cognitive training in adults with multiple sclerosis.
Plain-language title generated from the registry record
Registry title: Prepare the Mind: Can Coaching in Goal-directed Behaviour Increase the Success of Cognitive Rehabilitation in People With MS?
Key facts
- Where
- Rheinfelden, SwitzerlandSee the site
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 65 years old?
Source: NCT07225868, who can take part
Where in Switzerland
- Research Department, Reha RheinfeldenRheinfelden, SwitzerlandNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Universiteit Leiden
- Trial code
- NCT07225868
- Record updated
- 10 November 2025
- Original description
People with Multiple Sclerosis (MS) often experience cognitive difficulties such as memory problems, concentration issues, and reduced processing speed. These symptoms can have a negative impact on daily functioning and overall quality of life. Previous research on cognitive rehabilitation has shown that regular training focused on memory and concentration can have positive effects on cognitive functioning, including processing speed, memory, and executive functions that support daily activities. Moreover, fMRI studies (brain scans that measure brain activity) have revealed changes in brain activation following cognitive rehabilitation.Read full original descriptionShow less
Prepare the Mind: Can Coaching in Goal-directed Behaviour Increase the Success of Cognitive Rehabilitation in People With MS?
People with Multiple Sclerosis (MS) often experience cognitive difficulties such as memory problems, concentration issues, and reduced processing speed. These symptoms can have a negative impact on daily functioning and overall quality of life. Previous research on cognitive rehabilitation has shown that regular training focused on memory and concentration can have positive effects on cognitive functioning, including processing speed, memory, and executive functions that support daily activities. Moreover, fMRI studies (brain scans that measure brain activity) have revealed changes in brain activation following cognitive rehabilitation.
Recently, the idea has emerged that a more personalized approach could improve treatment outcomes. Specifically, researchers have identified a link between personality traits and cognitive functioning. Since every individual is different, current cognitive rehabilitation programs often fail to take these personal differences into account.
In this project, the investigators aim to enhance the effectiveness of cognitive rehabilitation by focusing more closely on individual characteristics through an app-based training program. Participants will complete a 12-week app training prior to a 6-week cognitive rehabilitation program. The first app focuses on mindset training, supported by a coach. Afterwards, all participants will use a second app designed to train processing speed and memory. In addition to cognitive functioning, the investigators will also examine psychological, (neuro)biological, and social changes using questionnaires and fMRI. This research may provide valuable insights into how cognitive functioning and quality of life in people with MS can be improved.
This study is funded by the National MS Fund and is a collaboration between several institutions: the Department of Health, Medical and Neuropsychology at Leiden University (The Netherlands), the University at Buffalo (USA), and Reha Rheinfelden (Switzerland).
Inclusion: Confirmed relapsing remitting or secondary progressive MS diagnosis according to the McDonald 2017 criteria; Expanded Disability Status Scale (EDSS) score < 7; Relapse free period ≥ 3 months; Unchanged disease modifying therapy for ≥ 2 months at time of inclusion; Age 18-65 years; Language Dutch, English or German for each centre respectively.
Exclusion: Current or prior brain trauma or neurological condition (other than MS); Medication intake and/or substance abuse that has an influence on cognitive functioning; Psychiatric disorder that heavily impacts cognitive and/or daily functioning; High conscientiousness, measured with a T score 65 or higher on the BFI-2 subscale for conscientiousness; For Dutch subsample undergoing MRI: Contradiction for MRI.