Endothelial Dysfunction After SCI
Key facts
- Where
- Englewood, United StatesSee the site
Where in United States
- Craig HospitalEnglewood, United StatesContact: Genevieve Madera, B.S.Taking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorTrial details
- Who runs it
- Craig Hospital
- Trial code
- NCT07227727
- Record updated
- 14 November 2025
- Original description
This study plans to learn how endothelial cells, single cell lining of blood vessels may be dysfunctional after a spinal cord injury. Endothelial dysfunction will be measured by the capacity of blood vessels to vasodilate (increase in size) and alter blood flow is lower in adults with a spinal cord injury in comparison to adults without a spinal cord injury. The mechanisms which may alter this function may be critical in reducing the risk of heart attacks and strokes in people with spinal cord injuries.Read full original descriptionShow less
Endothelial Dysfunction After SCI: Mechanism and Therapeutic Target for SCI-related Cardiovascular Disease
This study plans to learn how endothelial cells, single cell lining of blood vessels may be dysfunctional after a spinal cord injury. Endothelial dysfunction will be measured by the capacity of blood vessels to vasodilate (increase in size) and alter blood flow is lower in adults with a spinal cord injury in comparison to adults without a spinal cord injury. The mechanisms which may alter this function may be critical in reducing the risk of heart attacks and strokes in people with spinal cord injuries.
Exclusion: Recent (< 3 months) surgery; Currently taking cardiovascular (statins, beta-blockers) therapeutics and/or other medications that could influence the outcome measures; Overt chronic diseases as assessed by: a) clinically documented medical history; b) physical examination; c) blood pressure and ECG at rest; and d) complete blood chemistries and hematological evaluation; Active infection; History of drug abuse; Current smoking history (within past 12 months); Report more than low-risk alcohol consumption.
SCI Inclusion Criteria; Over age 18 years; Chronic (>12 months) SCI; Motor complete (AIS A/B) SCI; Paraplegia (neurological level of injury [NLI] at T2 or below); Non-injured Inclusion Criteria; Over age 18 years.