Tests two small devices for glaucoma that is not controlled by eye drops
Tests an eye stent and a travoprost implant in adults with uncontrolled open angle glaucoma.
Plain-language title generated from the registry record
Registry title: Standalone iStent Infinite and iDose TR for Management of Moderate to Severe Open Angle Glaucoma
Key facts
- Where
- Philadelphia, United StatesSee the site
- Phase
- Phase 4
Where in United States
- Wills Eye Hosital Glaucoma Dept.Philadelphia, United StatesTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Jonathon Myers
- Trial code
- NCT07228221
- Record updated
- 14 November 2025
- Original description
The Investigators will investigate the efficacy of combining the standalone iStent infinite and iDose that are minimally invasive surgical and drug depot options are a safe and effective alternative to filtering surgery for intraocuar pressure reduction in patients with medically uncontrolled open angle glaucoma.Read full original descriptionShow less
iStent Infinite and iDose TR for Management of Moderate to Severe Primary Open Angle Glaucoma Are a Safe and Effective Alternative to Filtering Surgery for IOP Reduction in Patients With Medically Uncontrolled Glaucoma. (POAG)
The Investigators will investigate the efficacy of combining the standalone iStent infinite and iDose that are minimally invasive surgical and drug depot options are a safe and effective alternative to filtering surgery for intraocuar pressure reduction in patients with medically uncontrolled open angle glaucoma.
Inclusion: Moderate to severe open angle glaucoma (including POAG, PG, and PXG); Open angle configuration (Shaffer grade ≥ 3), normal angle anatomy9; Visual acuity HM or better; VF MD -6dB or worse; Failed medical therapy and/or laser treatment; Incisional glaucoma surgery contemplated as next intervention; Phakic or pseudophakic.
Exclusion: Previous incisional glaucoma surgery; ALT; History of iridotomy, SLT, or micropulse laser trabeculoplasty within the prior 90 days; Traumatic, uveitic, neovascular glaucoma, or angle closure glaucoma; Active ocular inflammation or edema, clinically significant corneal dystrophy; Corneal or other pathology preventing accurate Goldmann applanation tonometry.