Tests SHR-4658 injection for safety in healthy adults and people with high blood pressure
Tests one SHR-4658 injection under the skin in healthy adults and high blood pressure.
Plain-language title generated from the registry record
Registry title: A Trial of SHR-4658 in Healthy Volunteers or Volunteers With Elevated Blood Pressure
Key facts
- Where
- Beijing, ChinaSee the site
- Phase
- Phase 1
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Are you between 18 and 55 years old?
Source: NCT07230145, who can take part
Where in China
- Beijing Anzhen Hospital, Capital Medical UniversityBeijing, ChinaNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Beijing Suncadia Pharmaceuticals Co., Ltd
- Trial code
- NCT07230145
- Record updated
- 17 November 2025
- Original description
This is a clinical study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamic and immunogenicity of single subcutaneous injection of SHR-4658 in healthy volunteers and volunteers with elevated blood pressure.Read full original descriptionShow less
A Double-Blind, Randomized, Dose-Escalating Phase I Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Single-Dose SHR-4658 in Healthy Volunteers or Volunteers With Elevated Blood Pressure
This is a clinical study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamic and immunogenicity of single subcutaneous injection of SHR-4658 in healthy volunteers and volunteers with elevated blood pressure.
Inclusion: Able and willing to provide a written informed consent; Blood pressure as defined in the protocol; Male or female，aged 18 to 55 years (inclusive); Meet the weight standard.
Exclusion: Participated in clinical trials of other drugs or medical devices; Known history or current clinically significant disease; Protocol-defined risk factors for disease; Pregnant or nursing women.