Observes outcomes of amivantamab treatment in lung cancer with EGFR mutations
Studies how amivantamab-based treatments work in adults with advanced EGFR-mutated lung cancer.
Plain-language title generated from the registry record
Registry title: A Study of Clinical Outcomes in Participants With EGFR Mutated Advanced Non-Small Cell Lung Cancer (NSCLC) in a Real-World Setting
Key facts
- Where
- Avellino, Aviano, Bari, Bergamo, Brescia, Candiolo, Catania, Catanzaro, Genova, Lecce, Milan, Monza, Naples, Novara, Olbia, Orbassano, Palermo, Parma, Pisa, Ravenna, Roma, Rome, Sassari, Torrette-Ancona, and Urbino, ItalySee the 31 sites
Could this be for you?
Answer for yourself. This is not a decision: only the study team can say whether you can take part.
- Which best describes your lung cancer?
- Has the cancer spread to other parts of the body, or is it too advanced to be removed by surgery?
Source: NCT07230691, who can take part
Where in Italy
- Ospedale San Giuseppe Moscati di AvellinoAvellino, ItalyTaking people
- CRO IRCCS Istituto Nazionale TumoriAviano, ItalyTaking people
- Oncologia Medica - Irccs - Istituto Tumori Giovanni Paolo IIBari, ItalyTaking people
- ASST Papa Giovanni XXIII BergamoBergamo, ItalyTaking people
- ASST Spedali Civili BresciaBrescia, ItalyTaking people
- Istituto di Candiolo, IRCCSCandiolo, ItalyTaking people
- PO G.Rodolico, AOU Policlinico-Vittorio Emanuele CataniaCatania, ItalyTaking people
- Azienda Ospedaliera Pugliese Ciaccio CatanzaroCatanzaro, ItalyTaking people
- Ospedale Policlinico San Martino IRCCSGenova, ItalyTaking people
- Azienda Ospedaliera ''Vito Fazzi''Lecce, ItalyTaking people
- ASST Grande Ospedale Metropolitano NiguardaMilan, ItalyTaking people
- European Institute of OncologyMilan, ItalyTaking people
- Istituto Dei Tumori Di MilanoMilan, ItalyTaking people
- San Raffaele HospitalMilan, ItalyTaking people
- San Gerardo HospitalMonza, ItalyTaking people
- Fondazione G Pascale Istituto Nazionale Tumori IRCCSNaples, ItalyTaking people
- Universita degli Studi della Campania Luigi VanvitelliNaples, ItalyTaking people
- Azienda Ospedaliero Universitaria Maggiore della Carita di NovaraNovara, ItalyTaking people
- ASL Gallura - Ospedale Giovanni Paolo IIOlbia, ItalyTaking people
- Aou San Luigi GonzagaOrbassano, ItalyTaking people
- A.O.R Villa Sofia CervelloPalermo, ItalyTaking people
- Azienda Ospedaliero Universitaria Policlinico Paolo GiacconePalermo, ItalyTaking people
- Azienda Ospedaliero Universitaria di ParmaParma, ItalyTaking people
- Azienda Ospedaliero Universitaria PisanaPisa, ItalyTaking people
- U.O.C. Ematologia Ospedale S. Maria delle CrociRavenna, ItalyTaking people
- Campus Bio Medico di RomaRoma, ItalyTaking people
- Fondazione Policlinico Universitario A. Gemelli IRCCSRoma, ItalyTaking people
- Istituto Nazionale Tumori Regina ElenaRome, ItalyTaking people
- Azienda Ospedaliero-Universitaria di SassariSassari, ItalyTaking people
- Ospedali Riuniti Di AnconaTorrette-Ancona, ItalyTaking people
- Azienda Sanitaria Territoriale Pesaro UrbinoUrbino, ItalyTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Janssen Research & Development, LLC
- Trial code
- NCT07230691
- Record updated
- 3 November 2026
- Original description
The purpose of this study is to describe the clinical and health-related outcomes of amivantamab-containing regimens for the treatment of common epidermal growth factor receptor (EGFR) mutated non-small cell lung cancer (NSCLC; most common type of lung cancer) in a real-world setting. Metastatic NSCLC is when this disease spreads to other parts of body. NSCLC may occur due to mutations (changes) in many genes including epidermal growth factor receptor (EGFR).Read full original descriptionShow less
Prospective, Multi Country, Observational Study of Clinical Outcomes in EGFR-mutated, Advanced Non-Small Cell Lung Cancer (NSCLC) Patients Treated With Approved Amivantamab-containing Regimens Under Standard Clinical Practice
The purpose of this study is to describe the clinical and health-related outcomes of amivantamab-containing regimens for the treatment of common epidermal growth factor receptor (EGFR) mutated non-small cell lung cancer (NSCLC; most common type of lung cancer) in a real-world setting. Metastatic NSCLC is when this disease spreads to other parts of body. NSCLC may occur due to mutations (changes) in many genes including epidermal growth factor receptor (EGFR).
Inclusion: Participant has a confirmed diagnosis of common epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) (EGFR exon 19 deletions or exon 21 L858R substitution) and is eligible for an amivantamab-containing regimen per the judgment of the treating physician and in alignment with the approved amivantamab indications and recommended prophylactic and reactive medication as described in the local specific summary of product characteristics (SmPC) for amivantamab; Participants or their legally acceptable representative, where applicable, must sign a participation agreement/Informed consent form (ICF) allowing source data verification in accordance with local requirements; Participant is being planned to be initiated with an amivantamab-containing regimen for the first time within 4 weeks following the visit for start of data collection; Decision to administer an amivantamab-containing regimen has been made prior to participant's enrollment in the study and is separate from the physician's decision to include the participant in the current study.
Exclusion: At the time of the initiation of the amivantamab-containing regimen, the participant is receiving an active systemic anticancer treatment for advanced NSCLC that is not included in the locally approved combination regimen with amivantamab (regardless of whether it is part of an interventional study). One cycle of platinum-based chemotherapy (for example, carboplatin-pemetrexed) is permitted prior to the first dose of amivantamab in a 1L while awaiting biopsy results; Participant has received prior treatment with amivantamab in a clinical trial or for compassionate use; Participants who are not receiving amivantamab but are being treated with a biosimilar or a non-original biologic agent; Participants with conditions listed in the contraindications of the SmPC for amivantamab or other agents essential for the applicable amivantamab-containing treatment regimen (lazertinib/ platinum/ pemetrexed).