Sodium Bicarbonate Tablets for High Blood Pressure During Dialysis
Tests sodium bicarbonate tablets against placebo in adults on dialysis with high blood pressure.
Plain-language title generated from the registry record
Registry title: Sodium Bicarbonate in Intra-dialytic Hypertension in Chronic Hemodialysis Patients
Key facts
- Where
- Tsrifin, IsraelSee the site
- Phase
- Phase 2/3
Where in Israel
- Shamir Medical CenterTsrifin, IsraelNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Assaf-Harofeh Medical Center
- Trial code
- NCT07231900
- Record updated
- 17 November 2025
- Original description
The study is designed to diminish intra-dialytic hypertension in chrnic hemodialysis patients suffering from metabolic acidosis (low bicarbonate levels). The intervention is a tab of 500 mg sodium bicarbonate twice a day for one month, vs. placebo.Read full original descriptionShow less
Sodium Bicarbonate in Intra-dialytic Hypertension in Chronic Hemodialysis Patients
The study is designed to diminish intra-dialytic hypertension in chrnic hemodialysis patients suffering from metabolic acidosis (low bicarbonate levels). The intervention is a tab of 500 mg sodium bicarbonate twice a day for one month, vs. placebo.
Inclusion: Chronic hemodialysis patient > 3 months; 3 dialysis per week, KTV>1.2; capable of informed concent; rise in blood pressure during hemodialysis > 10 mm Hg, for at least 50% of dialysis sessions in the month prior to inclusion; Normal volume status, by clinical physician assessment + bioimpedance.
Exclusion: planned for kidney transplant in the following 3 month; low compliece to medical therapy; congestive heart failure (NYHA 3-4); age under 18,; pregnancy; unable to sign informed concent; hospitalization for acute MI or CHF in the past 3 months; regular pre-dialysis tests with bicarbonate > 24 in the past 3 months.