Doppler-Guided Early Mobilization After Acute Ischemic Stroke in Adults
Tests Doppler-guided early mobilization in adults recovering from acute ischemic stroke.
Plain-language title generated from the registry record
Registry title: Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke
Key facts
- Where
- Rijeka and Zagreb, CroatiaSee the 2 sites
Where in Croatia
- University Hospital RijekaRijeka, CroatiaNot yet recruiting
- University Hospital Center ZagrebZagreb, CroatiaNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Unidade Local de Saúde de Coimbra, EPE
- Trial code
- NCT07232498
- Record updated
- 29 September 2026
- Original description
Post-stroke mobilization remains a subject of ongoing debate. While early mobilization-particularly the first out-of-bed mobilization-has been associated with reduced systemic complications and earlier rehabilitation, it also carries potential risks, such as neurological deterioration in the presence of hemodynamic instability.Read full original descriptionShow less
Early Doppler-Assisted Mobilization in Adults After Acute Ischemic Stroke - a Randomized Clinical Trial
Post-stroke mobilization remains a subject of ongoing debate. While early mobilization-particularly the first out-of-bed mobilization-has been associated with reduced systemic complications and earlier rehabilitation, it also carries potential risks, such as neurological deterioration in the presence of hemodynamic instability.
In this study, the primary aim is to investigate whether early mobilization, guided by hemodynamic evaluation after acute ischemic stroke offers superior outcomes compared to standard clinical care.
Inclusion: Patients diagnosed with ischemic stroke aged 18 years or older; Ability to undergo carotid and transcranial Doppler ultrasound, as well as to mobilize within 48 hours; Informed consent obtained from the patient or legal representative.
Exclusion: Concomitant diagnosis of a rapidly progressive fatal disease (e.g., terminal-stage cancer); Requirement for continuous monitoring or continuous intravenous drug infusion; Heart rate < 40 or > 112 beats per minute; Acute deep vein thrombosis/pulmonary embolism; Pre-existing disability with a modified Rankin Scale (mRS) score ≥ 4; Diagnosis of Transient Ischemic Attack (TIA); Severe hemodynamic instability, defined as:; Systolic blood pressure < 100 mmHg or > 220 mmHg; Peripheral oxygen saturation < 92%; Body temperature > 38.5°C; Neurological deterioration with altered level of consciousness (defined as Glasgow Coma Scale < 10); Patients who underwent neurosurgical intervention within the past 30 days.