Tests selenium and CoQ10 supplements for people with heart failure
Compares selenium and CoQ10 supplements with a placebo in adults with heart failure.
Plain-language title generated from the registry record
Registry title: The SELEQT-HF (SELEnium and CoQ10 NuTrition for Heart Failure) Study Will Evaluate the Effect of Adding Selenium/and coQ10 on Top of Standard HF Therapy in Patients With HF and Will do so Using a Pragmatic, Registry Based Randomized Controlled Trial in the Netherlands.
Key facts
- Where
- Alkmaar, Amsterdam, Breda, Eindhoven, Emmen, Groningen, and Nieuwegein, NetherlandsSee the 7 sites
- Phase
- Phase 3
Where in Netherlands
- Noordwest ZiekenhuisgroepAlkmaar, NetherlandsNot yet recruiting
- AUMCAmsterdam, NetherlandsNot yet recruiting
- Amphia ZiekenhuisBreda, NetherlandsTaking people
- Catharina Ziekenhuis EindhovenEindhoven, NetherlandsNot yet recruiting
- TreantEmmen, NetherlandsNot yet recruiting
- University Medical Center GroningenGroningen, NetherlandsTaking people
- St. Antonius ZiekenhuisNieuwegein, NetherlandsNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Netherlands Heart Institute
- Trial code
- NCT07234422
- Record updated
- 19 May 2026
- Original description
The goal of this clinical trial is to learn whether taking selenium and coenzyme Q10 (CoQ10) can reduce HF related events and deaths related to cardiovascular disease.Read full original descriptionShow less
A Registry-Based Randomised Controlled Trial With Heart 4 Data - SELEnium and CoQ10 NuTrition for Heart Failure: H4D-SELEQT-HF
The goal of this clinical trial is to learn whether taking selenium and coenzyme Q10 (CoQ10) can reduce HF related events and deaths related to cardiovascular disease.
Researchers will compare selenium-CoQ10 supplements with a placebo to see if the supplements improve heart health and patient outcomes.
Participants will:
Receive either selenium-CoQ10 or placebo in addition to their usual heart failure treatment
Attend standard clinical visits according to routine clinical care.
The study will include 1,100 adults with chronic heart failure. Selenium and CoQ10 are natural nutrients with no known health risks. If effective, this supplement could provide a safe new way to improve outcomes for people with heart failure.
Inclusion: Age >18 years; Outpatients with chronic HF, NYHA II - ambulatory IV; Serum NT-proBNP concentrations >600 pg/mL (71 pmol/L) if in sinus rhythm; >1000pg/mL (118 pmol/L) if in Atrial fibrillation*.
Exclusion: History of myocardial infarction, myocarditis, percutaneous intervention, cardiac surgery or stroke <30 days; Scheduled for mechanical assist device or heart transplant; Other non-cardiac conditions with limited life expectancy (<1 year); End stage kidney disease for which chronic intermittent peritoneal or haemodialysis; Peanut and/or soy allergy; The presence of a mechanical assist device; Amyloid, hypertrophic obstructive or constrictive cardiomyopathy; Unable to sign informed consent; (Unwilling to stop) use of over the counter supplements coQ10/selenium.