Comparing two anesthesia methods during clot removal for severe stroke
Compares general anesthesia with lighter sedation in adults having thrombectomy for stroke.
Plain-language title generated from the registry record
Registry title: Anesthesia Management in Endovascular Therapy for Ischemic Stroke - 2
Key facts
- Where
- Angers, Brest, Clermont-Ferrand, Lille, Lyon, Marseille, Montpellier, Nantes, Paris, Saint-Denis, Saint-Etienne, Strasbourg, Suresnes, Talence, Toulouse, and Tours, FranceSee the 16 sites
Where in France
- Le Centre Hospitalier Universitaire d'AngersAngers, FranceNo longer taking part
- Le Centre Hospitalier Universitaire Morvan de Brest de BrestBrest, FranceNot yet recruiting
- CHU de Clermont-FerrandClermont-Ferrand, FranceTaking people
- Le centre hospitalier universitaire de LilleLille, FranceTaking people
- Les Hospices Civils de LyonLyon, FranceTaking people
- L'Assistance Publique-Hôpitaux de MarseilleMarseille, FranceTaking people
- Le centre hospitalier universitaire de MontpellierMontpellier, FranceNot yet recruiting
- Le Centre Hospitalier Universitaire de NantesNantes, FranceTaking people
- L'Assistance Publique - Hôpitaux de ParisParis, FranceTaking people
- Le Centre Hospitalier Universitaire de La RéunionSaint-Denis, FranceNot yet recruiting
- Le Centre Hospitalier Universitaire de Saint-EtienneSaint-Etienne, FranceNot yet recruiting
- Le Centre Hospitalier Universitaire de StrasbourgStrasbourg, FranceNo longer taking part
- L'hôpital FochSuresnes, FranceNot yet recruiting
- Le Centre Hospitalier Universitaire de BordeauxTalence, FranceNo longer taking part
- Le Centre Hospitalier Universitaire de ToulouseToulouse, FranceTaking people
- Le Centre Hospitalier Universitaire de ToursTours, FranceNot yet recruiting
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Hospital, Clermont-Ferrand
- Trial code
- NCT07235514
- Record updated
- 2 September 2026
- Original description
The goal of this clinical trial is to learn what is the best anesthetic management in participants with severe stroke that require a medical intervention called mechanical thrombectomy (MT) done to open the occluded brain vessel.Read full original descriptionShow less
General Anesthesia Versus Procedural Sedation in Endovascular Therapy for Anterior Circulation Large Vessel Occlusion Stroke: A Multicenter Prospective Randomized Trial
The goal of this clinical trial is to learn what is the best anesthetic management in participants with severe stroke that require a medical intervention called mechanical thrombectomy (MT) done to open the occluded brain vessel.
The main question it aims to answer is:
• Is general anesthesia (GA) better than procedural sedation (PS) for improving functional performance and decrease dependance in daily life 3 months after stroke?
GA (a non-arousable state induced by anesthetic medications that require respiratory assistance) or PS (a state of reduced arousal induced by lesser dose of anesthetic medications that do not require respiratory assistance) are both used for MT. GA enables strict immobility that could facilitate the conduct of MT but lessen blood pressure and blood flow in the brain. PS provides less drop in blood pressure but MT could be more difficult due to possible movement and breathing may be decreased.
Researchers will compare GA with PS to see which one is better for MT success and for the functional consequences of stroke.
Participants will be treated with GA or PS for the intervention of MT and will be followed by researchers during their hospital stay and asked by a telephone interview how is their functional status 3 months after stroke.
Inclusion: Age ≥18 years; Acute ischemic stroke with an occlusion of the intracranial internal carotid artery and/or the proximal middle cerebral artery (M1-M2) with or without association of extracranial occlusion of the cervical internal carotid artery (tandem lesion); Eligible for mechanical thrombectomy according to international guidelines; Informed and signed consent of patient, or if he is unable to consent the consent of patient's relative or emergency procedure in the absence of relative; National health insurance.
Exclusion: Posterior circulation stroke; Associated cerebral hemorrhage; Stroke complicating another acute illness or postoperative stroke; Allergy to anesthetic medication; Coma or altered vigilance defined as a score ≥ 2 on the level of consciousness 1A subscale of the NIHSS; Premorbid disability defined as a mRS > 2; Emesis at arrival in angiosuite; Pregnant or breast-feeding women; Adult under the protection of the law.