The Effect of Two Different Analgesic Methods on QoR-40 Score in Primary Unilateral Knee Arthroplasties
Key facts
- Who runs it
- Ataturk University
- Where
- Türkiye1 site in 1 countryChoose a country to see its sites
- Trial code
- Status
- Completed
- People taking part
- 60 people enrolled
- Started
- 15 Jul 2023
- Ended
- 30 Dec 2025
- Type of study
- InterventionalOne group gets an existing treatment, for comparison.
- Treatments tested
- PRİMER TEK TARAFLI DİZ ARTOPLASTİSİNDE İKİ FARKLI ANALJEZİK YÖNTEMİ
- knee replacement
- Record updated
- 21 January 2026
Who can take part
- Age
- 18 years to 80 years
- Sex
- Women and men
- Healthy volunteers
- Can take part
The registry criteria, word for word
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Who can take part
- ≥18 years old
- ASA 1-2
- Those who gave written informed consent for their participation in the study
- Patients undergoing unilateral primary total knee arthroplasty for end-stage osteoarthritis or rheumatoid arthritis
Who cannot take part
- Those allergic to the drugs to be used in the study
- Preoperative hb, creatinine and electrolytes not within normal limits
- Patients with advanced kidney disease (defined as GFR<30) or severe liver disease
- Patients with poorly controlled diabetes mellitus (HbA1C>7.0 on pre-admission test)
- Patients undergoing revision total knee arthroplasty
- Opioid addiction
- Anticoagulants
- Those with cognitive dysfunction
- Patients with more than 40 degrees of knee misalignment (varus or valgus)
- BMI≥40 patients with
- Any associated intraoperative complications
- Pregnant or lactating female patients
This trial has no sites in United States.
It has sites in one country. Choose a country to see its sites.
About the trial
What the trial wants to find out
Total knee arthroplasty (TKA) is a very common operation that increases in frequency with advancing age. Similar to other surgical procedures, strategies are being developed to minimize morbidity and mortality while allowing for rapid recovery and early hospital discharge.
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TKA causes moderate to severe postoperative pain for most patients. The goal of pain control after TKA is to provide excellent analgesia, early mobilization and rehabilitation, and to minimize opioid use, including overprescription of opioids after discharge Multimodal, opioid-sparing strategies for postoperative pain control include regional analgesia techniques (e.g., peripheral nerve blocks, LA infiltration, continuous epidural analgesia, neuraxial opioids) in addition to multimodal systemic analgesics.
Periarticular injection (PAI), also called local infiltration analgesia, and adductor canal block (ACB), a peripheral nerve block, are increasingly used as a component of multimodal postoperative analgesia and have been shown to reduce pain scores and opioid consumption after TKA. However, the impact of these modalities on the quality of postoperative recovery is unknown. The most widely used method of measuring this is the quality of recovery 40 (QoR 40) questionnaire. This questionnaire places increasing emphasis on measuring overall patient recovery and how quickly a patient can return to daily life after anesthesia and surgery.
Numerous studies have used the postoperative QoR-40 to compare different methods of anesthesia, adjuvants, regional analgesic techniques, and other factors on patient recovery and have been validated in Turkish.
The group in the trial
- THE EFFECT OF TWO DIFFERENT ANALGESIC METHODSExisting treatment, for comparison
Patients will be randomized into two equal groups by a statistician using a computerized random numbers table: Group 1 (PAI+ACB): Patients will undergo periarticular injection (PAI) by the surgeon with 120 ml of local anesthetic-containing fluid before cementing, and receive an adductor canal block (ACB) with 15 ml of 0.25% bupivacaine and 1:200,000 adrenaline at the end of the operation. Group 2 (ACB): Patients will receive an adductor canal block catheter placed at the end of the operation and will receive 0.1% bupivacaine through this catheter as a bolus every three hours postoperatively.
Treatment: PRİMER TEK TARAFLI DİZ ARTOPLASTİSİNDE İKİ FARKLI ANALJEZİK YÖNTEMİ and knee replacement
Data and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- The Effect of Two Different Analgesic Methods on QoR-40 Score in Primary Unilateral Knee Arthroplasties: A Prospective, Randomized Study
- Record updated
- 21 January 2026