Surgical Treatment for Atrial Fibrillation During Heart Surgery in Adults
Studies a standard surgical procedure to treat irregular heartbeat during heart surgery.
Plain-language title generated from the registry record
Registry title: Modified Left Atrial Maze Procedure for Concomitant AF Ablation
Key facts
- Where
- Toulouse, FranceSee the site
Where in France
- Myriam ADDIToulouse, FranceNo longer taking part
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- University Paul Sabatier of Toulouse
- Trial code
- NCT07236398
- Record updated
- 5 December 2025
- Original description
Atrial fibrillation (AF) is the most common sustained arrhythmia and affects up to 60% of patients undergoing cardiac surgery. Restoring sinus rhythm improves symptoms, reduces stroke risk, and prevents heart failure. Despite guideline recommendations, surgical ablation remains underused.Read full original descriptionShow less
Modified Left Atrial Maze Procedure: Achieving a Balance Between Safety and Efficacy in Concomitant Atrial Fibrillation Ablation
Atrial fibrillation (AF) is the most common sustained arrhythmia and affects up to 60% of patients undergoing cardiac surgery. Restoring sinus rhythm improves symptoms, reduces stroke risk, and prevents heart failure. Despite guideline recommendations, surgical ablation remains underused.
This study evaluates the safety and effectiveness of a standardized modified left atrial Maze procedure performed concomitantly with cardiac surgery and identifies early predictors of long-term rhythm success. The procedure consists of creating left atrial lesion sets using radiofrequency, cryothermy, or both, and systematically closing the left atrial appendage to reduce thromboembolic risk.
This prospective single-center observational study includes 151 patients undergoing concomitant AF ablation. Follow-up is performed at 3, 6, and 12 months with clinical evaluation, ECG, 24-hour Holter monitoring, pacemaker interrogation when applicable, and a standardized quality-of-life questionnaire.
The primary endpoint is sinus rhythm maintenance at 12 months. Secondary endpoints include operative mortality, neurological events, pacemaker implantation, reoperation for bleeding, and quality-of-life changes. The study aims to provide new insights into predictors of success and support standardized follow-up strategies for surgical AF ablation.
Inclusion: Age 18 years or older; Documented history of atrial fibrillation; Scheduled for cardiac surgery; Able to understand study information and provide non-opposition consent.
Exclusion: None.