Surgical Treatment for Atrial Fibrillation During Heart Surgery in Adults
Studies a standard surgical procedure to treat irregular heartbeat during heart surgery.
Key facts
- Who runs it
- University Paul Sabatier of Toulouse
- Where
- Toulouse, FranceSee the site
- Trial code
- Registry title
- Modified Left Atrial Maze Procedure for Concomitant AF Ablation
- Status
- Enrolling by invitation
- People taking part
- 151 people, planned
- Started
- 8 Jun 2023
- Planned end
- 15 Dec 2025
- Type of study
- Observational
- Treatments tested
- Modified left atrial Maze procedure performed concomitantly with cardiac surgery, including left atrial appendage closure, using bipolar radiofrequency and/or cryotherapy.
- Record updated
- 5 December 2025
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with a documented history of atrial fibrillation who are scheduled for heart surgery and will have a Maze ablation procedure during that surgery.
- Age
- 18 years or older
- Sex
- All sexes can join.
- Disease stage
- Documented history of atrial fibrillation.
Main reasons for not taking part
- The record lists no exclusion criteria.
The registry criteria, word for word
Show all 5 criteriaShow less
Who can take part
- Age 18 years or older
- Documented history of atrial fibrillation
- Scheduled for cardiac surgery
- Able to understand study information and provide non-opposition consent
Who cannot take part
- None
Where in France
- Myriam ADDIToulouse, FranceNo longer taking part
About the trial
What the trial wants to find out
Atrial fibrillation (AF) is the most common sustained arrhythmia and affects up to 60% of patients undergoing cardiac surgery. Restoring sinus rhythm improves symptoms, reduces stroke risk, and prevents heart failure. Despite guideline recommendations, surgical ablation remains underused.
Read full original descriptionShow less
This study evaluates the safety and effectiveness of a standardized modified left atrial Maze procedure performed concomitantly with cardiac surgery and identifies early predictors of long-term rhythm success. The procedure consists of creating left atrial lesion sets using radiofrequency, cryothermy, or both, and systematically closing the left atrial appendage to reduce thromboembolic risk.
This prospective single-center observational study includes 151 patients undergoing concomitant AF ablation. Follow-up is performed at 3, 6, and 12 months with clinical evaluation, ECG, 24-hour Holter monitoring, pacemaker interrogation when applicable, and a standardized quality-of-life questionnaire.
The primary endpoint is sinus rhythm maintenance at 12 months. Secondary endpoints include operative mortality, neurological events, pacemaker implantation, reoperation for bleeding, and quality-of-life changes. The study aims to provide new insights into predictors of success and support standardized follow-up strategies for surgical AF ablation.
Treatments tested
- Modified left atrial Maze procedure performed concomitantly with cardiac surgery, including left atrial appendage closure, using bipolar radiofrequency and/or cryotherapy.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Modified Left Atrial Maze Procedure: Achieving a Balance Between Safety and Efficacy in Concomitant Atrial Fibrillation Ablation
- Plain-language title
- Surgical Treatment for Atrial Fibrillation During Heart Surgery in AdultsGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 5 December 2025