Following Heart Artery Plaque Over Time in Type 2 Diabetes
Follows adults with type 2 diabetes to track changes in heart artery plaque.
Key facts
- Who runs it
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- Where
- Amsterdam, NetherlandsSee the 2 sites
- Trial code
- Registry title
- Evaluating Atherosclerotic Disease Progression in Patients With Diabetes Mellitus
- Status
- Recruiting
- People taking part
- 1,000 people, planned
- Started
- 6 Jun 2025
- Expected to end
- 1 Oct 2036
- Type of study
- Observational
- Record updated
- 20 November 2025
Who can take part
AI summary
From the trial's eligibility criteria. Machine-read from the registry text on this page, so it can be wrong. The registry text below and the trial team decide who can take part.
The trial is looking for adults with type 2 diabetes who take glucose-lowering treatment and have already had a heart scan called coronary CT angiography (CCTA).
- Age
- Over 18 years
- Sex
- All sexes
- Disease stage
- Type 2 diabetes with a previous CCTA scan done to check for coronary artery disease. At least 2 of 3 vessels on the scan must be of good enough quality.
- Earlier treatment
- Must currently be receiving glucose-lowering treatment. The earlier CCTA scan must have been done more than 2 years and less than 5 years before joining.
Main reasons for not taking part
- Cannot give written informed consent
- Has an unstable condition
- Severe kidney problems (eGFR ≤ 30 mL/min/1.73m²) or known allergy or other problem with CT contrast agents
- Another treatment or condition that could interfere with the study, in the investigator's opinion
- Cannot or will not follow the study requirements
The registry criteria, word for word
Show all 10 criteriaShow less
Who can take part
- Age over 18 years
- Previous completion of CCTA scan for CAD assessment
- Diagnosed with Type 2 Diabetes and currently receiving glucose lowering treatment
- Sufficient image quality of the CCTA scan (at least 2/3 vessels of sufficient quality for assessment)
Who cannot take part
- Presence of an unstable condition
- Any other treatment or clinically relevant condition that could interfere with the conduct or interpretation of the study in the opinion of the investigator
- Ingeligibility for CCTA acquisition due to severe renal dysfunction (eGFR ≤ 30 mL/min/1.73m²) or known hypersensitivity or contraindication to CT contrast agents
- Baseline (routine care) CCTA performed < 2 years or > 5 years before inclusion
- Inability to provide written informed consent
- inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study
Where in Netherlands
- Amsterdam University Medical CentersAmsterdam, NetherlandsContact: Willem R van de VijverNot yet recruiting
- Cardiology Centers of the NetherlandsAmsterdam, NetherlandsContact: Willem R van de Vijver, MDTaking people
About the trial
What the trial wants to find out
People with type 2 diabetes have a much higher risk of heart disease. One common problem is when the blood vessels that supply the heart become narrowed or blocked by fatty deposits, called plaque. This makes it harder for blood to reach the heart and can lead to serious problems such as chest pain, heart attacks, or even death.
Read full original descriptionShow less
This study will follow people with type 2 diabetes who have already had a special heart scan called a coronary CT angiography. This scan takes detailed pictures of the heart's blood vessels.
The goal is to understand how heart disease changes over time in people with type 2 diabetes, by looking at repeat scans and other health information. By learning more about how plaque builds up or gets worse, researchers hope to find better ways to identify which patients are most at risk for future heart problems.
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Contact the study team: see the registry record → Contacts and Locations
Print a page for my doctorData and sources
- Registry record
- Listed on ClinicalTrials.gov.
- Official title
- Evaluating Atherosclerotic Disease Progression in High-Risk Patients With Diabetes Mellitus
- Plain-language title
- Following Heart Artery Plaque Over Time in Type 2 DiabetesGenerated from the registry record. The registry title is the official one.
- AI summary
- From the trial's eligibility criteria. Read by machine on 12 November 2026.
- Record updated
- 20 November 2025