Following Heart Artery Plaque Over Time in Type 2 Diabetes
Follows adults with type 2 diabetes to track changes in heart artery plaque.
Plain-language title generated from the registry record
Registry title: Evaluating Atherosclerotic Disease Progression in Patients With Diabetes Mellitus
Key facts
- Where
- Amsterdam, NetherlandsSee the 2 sites
Where in Netherlands
- Amsterdam University Medical CentersAmsterdam, NetherlandsNot yet recruiting
- Cardiology Centers of the NetherlandsAmsterdam, NetherlandsTaking people
Questions to ask the study team
- How often do I need to come in, and for how long each time?
- Are travel costs paid?
- Can I keep my own doctor?
- What happens if I want to stop?
Trial details
- Who runs it
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
- Trial code
- NCT07237685
- Record updated
- 20 November 2025
- Original description
People with type 2 diabetes have a much higher risk of heart disease. One common problem is when the blood vessels that supply the heart become narrowed or blocked by fatty deposits, called plaque. This makes it harder for blood to reach the heart and can lead to serious problems such as chest pain, heart attacks, or even death.Read full original descriptionShow less
Evaluating Atherosclerotic Disease Progression in High-Risk Patients With Diabetes Mellitus
People with type 2 diabetes have a much higher risk of heart disease. One common problem is when the blood vessels that supply the heart become narrowed or blocked by fatty deposits, called plaque. This makes it harder for blood to reach the heart and can lead to serious problems such as chest pain, heart attacks, or even death.
This study will follow people with type 2 diabetes who have already had a special heart scan called a coronary CT angiography. This scan takes detailed pictures of the heart's blood vessels.
The goal is to understand how heart disease changes over time in people with type 2 diabetes, by looking at repeat scans and other health information. By learning more about how plaque builds up or gets worse, researchers hope to find better ways to identify which patients are most at risk for future heart problems.
Inclusion: Age over 18 years; Previous completion of CCTA scan for CAD assessment; Diagnosed with Type 2 Diabetes and currently receiving glucose lowering treatment; Sufficient image quality of the CCTA scan (at least 2/3 vessels of sufficient quality for assessment).
Exclusion: Presence of an unstable condition; Any other treatment or clinically relevant condition that could interfere with the conduct or interpretation of the study in the opinion of the investigator; Ingeligibility for CCTA acquisition due to severe renal dysfunction (eGFR ≤ 30 mL/min/1.73m²) or known hypersensitivity or contraindication to CT contrast agents; Baseline (routine care) CCTA performed < 2 years or > 5 years before inclusion; Inability to provide written informed consent; inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study.